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《Comparative metabolism of Radix scutellariae extract by intestinal bacteria from normal and type 2 diabetic mice in vitro 》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、JournalofEthnopharmacology153(2014)368–374ContentslistsavailableatScienceDirectJournalofEthnopharmacologyjournalhomepage:www.elsevier.com/locate/jepResearchPaperComparativemetabolismofRadixscutellariaeextractbyintestinalbacteriafromnormalandtype2diabeticmiceinvitronJunXu,Mi
2、nZhao,DaweiQian,Er-xinShang,ShuJiang,JianmingGuo,1Jin-aoDuan,LeyueDuJiangsuCollaborativeInnovationCenterofChineseMedicinalResourcesIndustrialization,NanjingUniversityofChineseMedicine,138XianlinRoad,Nanjing210023,PRChinaarticleinfoabstractArticlehistory:Ethnopharmacological
3、relevance:TraditionalChinesemedicine(TCM)hasbeenusedinclinicalpracticeforReceived29September2013severalthousandyears.TCMhasplayedanindispensableroleinthepreventionandtreatmentofdisease,Receivedinrevisedformespeciallythecomplicatedandchronicones.InTCMs,manyingredientswhichar
4、eknowntohave1February2014biologicaleffectsjustpassthroughthegut,theydonotgetintothebloodstream.StudyoninteractionsofAccepted11February2014theseactiveingredientswiththeintestinalbacteriaisveryhelpfultounravelhowTCMworks.Availableonline12March2014Radixscutellariaewaswidelyuse
5、daloneorincombinationwithothermedicinalherbstothetreatmentKeywords:oftype2diabetesmellitusforalongtimeinChinaeveninAsia.Additionally,theincidenceoftypeType2diabetes2diabetesiscloselyrelatedtothechangesofintestinalflora.Inthispaper,themetabolismofbaicalininUPLC-Q-TOF/MSRadixs
6、cutellariaeextractbynormalandtype2diabeticmiceintestinalbacteriawerefirstlyinvestigated.RadixscutellariaeMaterialsandmethods:Ultraperformanceliquidchromatography/quadrupole-time-of-flightmassspectro-BaicalinTMmetry(UPLC/QTOF-MS)techniquecombinedwithMetabolynxsoftwarewasusedfo
7、ranalysisoftheIntestinalbacteriametabolicprofileofbaicalininRadixscutellariaeextractsbytheintestinalbacteriafromnormalandtype2diabeticmice.Results:Theamountofbaicalin'saglycone(baicalein)intype2diabeticmicesampleswereremarkablymorethanthatinnormalmicesamplesandoroxylinAonlye
8、xistedintype2diabeticmicesamples.Intestinalbacteriaproducednotonlyasmallamountofba
