资源描述：
《22.Consequences of bile salt biotransformations by intestinal bacteria 》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、GutMicrobesISSN:1949-0976(Print)1949-0984(Online)Journalhomepage:http://www.tandfonline.com/loi/kgmi20ConsequencesofbilesaltbiotransformationsbyintestinalbacteriaJasonM.Ridlon,SpencerC.Harris,ShivaBhowmik,Dae-JoongKang&PhillipB.HylemonTocitethisarticle:JasonM.Ridlon,Spencer
2、C.Harris,ShivaBhowmik,Dae-JoongKang&PhillipB.Hylemon(2016)Consequencesofbilesaltbiotransformationsbyintestinalbacteria,GutMicrobes,7:1,22-39,DOI:10.1080/19490976.2015.1127483Tolinktothisarticle:http://dx.doi.org/10.1080/19490976.2015.1127483Publishedonline:03Mar2016.Submity
3、ourarticletothisjournalArticleviews:609ViewrelatedarticlesViewCrossmarkdataCitingarticles:1ViewcitingarticlesFullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=kgmi20Downloadby:[WenzhouMedicalCollege]Date:06April20
4、17,At:00:27GUTMICROBES2016,VOL.7,NO.1,22–39http://dx.doi.org/10.1080/19490976.2015.1127483REVIEWConsequencesofbilesaltbiotransformationsbyintestinalbacteriaabcbbJasonM.Ridlon,SpencerC.Harris,ShivaBhowmik,Dae-JoongKang,andPhillipB.HylemonabDepartmentofAnimalSciences,Universi
5、tyofIllinoisUrbana-Champaign,Urbana,IL,USA;DepartmentofMicrobiologyandImmunology,cVirginiaCommonwealthUniversity,Richmond,VA,USA;DepartmentofIntegrativeStructuralandComputationalBiology,TheScrippsResearchInstitute,LaJolla,CA,USAABSTRACTARTICLEHISTORYEmergingevidencestrongly
6、suggestthatthehuman“microbiome”playsanimportantroleinbothReceived5October2015healthanddisease.BileacidsfunctionbothasdetergentsmoleculespromotingnutrientabsorptionRevised5November2015intheintestinesandashormonesregulatingnutrientmetabolism.BileacidsregulatemetabolismAccepte
7、d28November2015viaactivationofspecificnuclearreceptors(NR)andG-proteincoupledreceptors(GPCRs).TheKEYWORDScirculatingbileacidpoolcompositionconsistsofprimarybileacidsproducedfromcholesterolinbileacid7a-dehydroxylation;theliver,andsecondarybileacidsformedbyspecificgutbacteria.T
8、hevariousbiotransformationofbileacidoxidoreductases;bileacidscarriedoutbygutbacter
