资源描述：
《56.The Role of Intestinal Microbiota in Acute Graft-versus-Host Disease 》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、HindawiPublishingCorporationJournalofImmunologyResearchVolume2015,ArticleID145859,9pageshttp://dx.doi.org/10.1155/2015/145859ReviewArticleTheRoleofIntestinalMicrobiotainAcuteGraft-versus-HostDisease12121,2YuanyuanChen,YeZhao,QiaoCheng,DepeiWu,andHaiyanLiu1Laborat
2、oryofCellularandMolecularTumorImmunology,JiangsuKeyLaboratoryofInfectionandImmunity,InstitutesofBiologyandMedicalSciences,SoochowUniversity,Suzhou215123,China2CyrusTangHematologyCenter,DepartmentofHematology,JiangsuInstituteofHematology,CollaborativeInnovationCen
3、terofHematology,TheFirstAffiliatedHospitalofSoochowUniversity,Suzhou215006,ChinaCorrespondenceshouldbeaddressedtoHaiyanLiu;hliu@suda.edu.cnReceived25December2014;Revised16February2015;Accepted28February2015AcademicEditor:PedroGiavina-BianchiCopyright©2015Yuanyuan
4、Chenetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.Themammalianintestinalmicrobiotaisacomplexecosystemthatplaysanimporta
5、ntroleinhostimmuneresponses.Recentstudieshavedemonstratedthatalterationsinintestinalmicrobiotacompositionarelinkedtomultipleinflammatorydiseasesinhumans,includingacutegraft-versus-hostdisease(aGVHD).aGVHDisoneofthemajorobstaclesinallogeneichematopoieticstemcelltr
6、ansplantation(allo-HSCT),characterizedbytissuedamageinthegastrointestinal(GI)tract,liver,lung,andskin.Here,wereviewthecurrentunderstandingoftheroleofintestinalmicrobiotainthecontrolofimmuneresponsesduringaGVHD.Additionally,thepossibilityofusingprobioticstrainsfor
7、potentialtreatmentorpreventionofaGVHDwillbediscussed.1.Introductiontumors,bonemarrowfailure,andcongenitalmetabolicdisorders.However,thedevelopmentofacutegraft-versus-Themammaliangastrointestinal(GI)tractharborsadensehostdisease(aGVHD)limitsthesuccessofallo-HSCTan
8、danddiversemicrobialcommunity,whichiscomposedpri-isfataltoapproximately15%oftransplantrecipients[13,14].marilyofbacteriabutalsoincludesfungi,archaea,andaGVHDre
