资源描述：
《Chromatin Remodeling： INO80 and SWR1》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、SnapShot:ChromatinRemodeling:INO80andSWR1YunheBaoandXuetongShenDepartmentofMolecularCarcinogenesis,M.D.AndersonCancerCenter,Smithville,TX78957,USAINO80SWR1Swc3Swc2Act1Arp8Arp4Taf14Arp5Rvb1,2Arp6Swc6Nhp10Ino80Act1TopviewSideviewles3Arp4les1Swc7Swc5les2les6Rvb1Swr1les4les5Bdf1Yaf9Rvb1Rvb2A
2、ct1Swc4Rvb2RemodelingmechanismATPADP+PiIno80Ino80ActinArp4ActinArp4NucleosomeslidingAAAZZZATPADP+PiSwr1Swc2FirstH2A.Z-H2BSecondH2A.Z-H2BArp4ActindimerexchangedimerexchangeActinArp4Swc2Swr1Swr1Swr1Swr1Swc2Swc2Swc2ActinArp4H2A.ZH2BH2AH2BActinArp4ActinArp4ATPADP+PiINO80biologicalfunctionsSW
3、R1biologicalfunctionsTranscriptionrepressionandactivationH2A.Zdepositionflankingnucleosome-freeregionaroundtranscriptionsiteXTranscriptionH2A.ZH2BfactorsSWR1INO80TranscriptionfactorsLoadingofH2A.ZaroundDSBDNArepairandcheckpointregulationMRXPPPPPPPPPINO80RPAMec1SWR1Replicationforkstabiliza
4、tionReplicationforkprogressionDNAdamagetolerancePPPReplisomeReplisomeRepairCheckpointfactorsfactorsH2A.ZdepositionattheboundaryofeuchromatinandheterochromatinStressNormalINO80conditionINO80conditionSIRCheckpointfactors?SWR1Rad18PCNA158Cell144,January7,2010©2010ElsevierInc.DOI10.1016/j.ce
5、ll.2010.12.024Seeonlineversionfor???SnapShot:ChromatinRemodeling:INO80andSWR1YunheBaoandXuetongShenDepartmentofMolecularCarcinogenesis,M.D.AndersonCancerCenter,Smithville,TX78957,USATheINO80andSWR1complexesbelongtotheINO80subfamilyofATP-dependentchromatin-remodelingcomplexes.Thesecomplex
6、esinteractwithnucleosomesandremodelchromatinbyeitherslidingnucleosomesalongtheDNAorexchanginghistoneswithinnucleosomes.Indoingso,theINO80andSWR1complexespromoterecruitmentofregulatoryfactorstoDNA.Distinctfromothersubfamiliesofchromatin-remodelingcomplexes,INO80andSWR1containcoreATPaseswi
7、thauniquesplitATPasedomain,aswellasRvbproteins,whichsharelimitedhomologytobacterialRuvB,theHollidayjunctionDNAhelicase.TheybindtohistoneH2Avariants(H2AXandH2A.Z)andhavebeenimplicatedinthealterationofchromatinstructureduringtranscription,replication,andDNArepair.ThisSnapSh
