myocardial remodeling.pdf

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1、PH73CH03-SpinaleARI7January201111:49MyocardialRemodeling:CellularandExtracellularEventsandTargetsJenniferA.Dixon1,2andFrancisG.Spinale1,21DivisionofCardiothoracicSurgery,MedicalUniversityofSouthCarolina,Charleston,SouthCarolina29425;email:wilburnm@musc.edu2RalphH.JohnsonVeteransAffa

2、irsMedicalCenter,Charleston,SouthCarolina29401Annu.Rev.Physiol.2011.73:47–68KeywordsTheAnnualReviewofPhysiologyisonlineatmatrixmetalloproteinases,large-animalmodels,myocardialinfarctionphysiol.annualreviews.orgbyNovartisAGon07/28/12.Forpersonaluseonly.Thisarticle’sdoi:Abstract10.114

3、6/annurev-physiol-012110-142230Thefocusofthisreviewisontranslationalstudiesutilizinglarge-animalCopyrightc2011byAnnualReviews.modelsandclinicalstudiesthatprovidefundamentalinsightintocellularAllrightsreservedandextracellularpathwayscontributingtopost–myocardialinfarctionAnnu.Rev.Ph

4、ysiol.2011.73:47-68.Downloadedfromwww.annualreviews.org0066-4278/11/0315-0047$20.00(MI)leftventricle(LV)remodeling.Specifically,bothlarge-animalandclinicalstudieshaveexaminedthepotentialroleofendogenousandex-ogenousstemcellstoalterthecourseofLVremodeling.Interestingly,therehavebeenal

5、terationsinLVremodelingwithstemcelltreatmentdespitealackoflong-termcellengraftment.Thetranslationofthefullpotentialofstemcelltreatmentstoclinicalstudieshasyettobereal-ized.Themodulationofproteolyticpathwaysthatcontributetothepost-MIremodelingprocesshasalsobeenexamined.Onthebasisofre

6、centlarge-animalstudies,thereappearstobearelationshipbetweenstemcelltreatmentpost-MIandthemodificationofproteolyticpath-ways,generatingthehypothesisthatstemcellsleaveanechoeffectthatmoderatesLVremodeling.47PH73CH03-SpinaleARI7January201111:49INTRODUCTIONextracellularpathwayscontribut

7、ingtopost-MIremodelingareemphasized.Myocardialremodelingisacontinuumofchangesinthestructureandfunctionofthemyocardiumthatcommonlyoccurasaresultofapathologicalprocess.AdversemyocardialLEFTVENTRICULARremodelingisassociatedwithpoorpatientREMODELINGANDSTEMCELLSoutcomesinthecontextofisch

8、emicheartEndogenous