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1、BiochemicalandBiophysicalResearchCommunications391(2010)73–77ContentslistsavailableatScienceDirectBiochemicalandBiophysicalResearchCommunicationsjournalhomepage:www.elsevier.com/locate/ybbrcCirculatingmicroRNA-1asapotentialnovelbiomarkerforacutemyocardialinfarctiona,1a,1cga,bdhe
2、cJingAi,RongZhang,YueLi,JielinPu,YanjieLu,JundongJiao,KangLi,BoYu,ZhuqinLi,gffaaaa,b,*RongrongWang,LihongWang,QiangLi,NingWang,HongliShan,ZhongyuLi,BaofengYangaTheDepartmentofPharmacology,HarbinMedicalUniversity,Harbin150081,PRChinabTheState-ProvinceKeyLaboratoryofBiomedicineand
3、Pharmaceutics,HarbinMedicalUniversity,Harbin150081,PRChinacTheDepartmentofCardiologyoftheFirstAffiliatedHospital,HarbinMedicalUniversity,Harbin150001,PRChinadTheDepartmentofNephrologyoftheSecondAffiliatedHospital,HarbinMedicalUniversity,Harbin150086,PRChinaeTheDepartmentofCardiolo
4、gyoftheSecondAffiliatedHospital,HarbinMedicalUniversity,Harbin150086,PRChinafTheDepartmentofEndocrinologyandMetabolismoftheSecondAffiliatedHospital,HarbinMedicalUniversity,Harbin150086,PRChinagFuwaiHospital,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Peking100037,P
5、RChinahTheDepartmentofBiostatistics,HarbinMedicalUniversity,Harbin150081,PRChinaarticleinfoabstractArticlehistory:RecentstudieshaverevealedtheroleofmicroRNAs(miRNAs)inavarietyofbasicbiologicalandpatho-Received18October2009logicalprocessesandtheassociationofmiRNAsignatureswithhum
6、andiseases.CirculatingmiRNAshaveAvailableonline5November2009beenproposedassensitiveandinformativebiomarkersformultiplecancersdiagnosis.Wehaveprevi-ouslydocumentedaberrantup-regulationofmiR-1expressioninischemicmyocardiumandtheconse-Keywords:quentslowingofcardiacconduction.Howeve
7、r,whethermiR-1couldbeabiomarkerforpredictingAcutemyocardialinfarctionacutemyocardialinfarction(AMI)isunclear.Inthepresentstudy,werecruited159patientswithorBiomarkerswithoutAMIforquantificationofmiR-1levelinplasmausingreal-timeRT-PCRmethod.WeperformedDiagnosisWilcoxonranksumandsig
8、nedranktestsforcomparison.Univariablelinearregr
