Analysis of bone remodeling in the tibia after total knee prosthesis英文学习材料

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1、AnalysisofboneremodelinginthetibiaaftertotalkneeprosthesisTiagoJoséFonsecaRobaloDissertationforobtainingtheMaster’sDegreeinBiomedicalEngineeringJuryPresident:Prof.PauloFreitasAdvisers:Prof.JoãoFolgadoProf.PauloFernandesExternalspecialist:Prof.JoãoGamelasISTspecialist:Prof.LuísSousaNov

2、ember2011IAcknowledgementsFirstofall,Iwouldliketothankmyadvisors,Prof.JoãoFolgadoandProf.PauloFernandes,foralltheiravailabilityintheclarificationofdoubtsandalsofortheirsupportthroughthesuggestionstoguidemywork.IalsoexpressmygratitudetoProf.Dr.JoãoGamelasforalltheclinicalguidanceandfor

3、providingmetheopportunitytoattendasurgicalprocedureoftheknee.Inadditiontomyadvisors,IamalsothankfultotheentireIDMECresearchgroupforsharingtheirknowledgeandexpertisewithme.EspeciallytoCarlosQuental,LinaEspinhaandMartaDiasthatgavemeagreatassistancethroughoutthisresearch,andtoPaulaFernan

4、desandÂngelaChanthathelpedmeinthepreparationofthegeometricmodels.Finally,Iwouldalsoliketothankmyfamilyforeverythingtheydidforme.IIIIIAbstractTotalkneearthroplastyisasurgicaltreatmentwithoneofthehighestusagerate,makingitthegoldstandardtreatmentforadvancedosteoarthritisoftheknee.However

5、,kneeprosthesiscurrentlyusedstilllackappropriatedesignsolutions.Thelossofboneinthetibiaduetotibialcomponentisoneoftheconcernsaboutthesuccessofthekneeprosthesis.Thepurposeofthepresentworkistoevaluatetheboneremodelingthatoccursinthetibiaaftertotalkneearthroplasty.Athree-dimensionalmodel

6、ofthetibiawasdevelopedfromCTimages.Thegeometricmodelingofthetibialcomponents,aswellastheirdiscretizationinfiniteelements(FE)werealsomade.Bonewasmodeledasaporousmaterialcharacterizedbyitsrelativedensityateachpointofthedomain.Theboneremodelinglawwasderivedfromatopologyoptimizationproble

7、m,inwhichboneself-adaptsinordertoachievethestiffeststructure,beingthetotalbonemassregulatedbythemetaboliccostassociatedwithbonemaintenance.ByusingtheFEmethodtogetherwiththeboneremodelingmodeldevelopedinISTitwaspossibletoanalyzethephysiologicalsituationofbone,andalsoitsbehaviorindiffer

8、entsu