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ID:39118858
大小:1.31 MB
页数:43页
时间:2019-06-25
《大鼠切口痛模型上右美托咪定对瑞芬太尼诱发的痛觉过敏的影响与机制》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、徐州医学院硕士研究生论丈12.30±2.21s)的PMWT值和PWTL值均明显降低(P2、太尼诱发的切口周围组织的PWTL值的降低(P>O.05);RD2组、RD3组可以缓解T1(13.75±1.72g,14.03±1.01g)、T2(13.14+-2.21g,14.274-1.33g)、1"3(12.78+-2.75g,14.26+-1.58g)时点瑞芬太尼诱发的大鼠切口周围组织的PMWT值的降低(P3、.05)。(2)Westernblot的结果:与C组(0.06±0.01)相比,I组(O.384-0.03)可以引起术后48h时L4.5脊髓背角磷酸化NR2B表达的增加(P4、0.02)均可抑制由瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。结论在大鼠切口痛模型上,(1)瑞芬太尼可以诱发切口周围组织的痛觉过敏;(2)右美托咪定可以预防瑞芬太尼诱发的痛觉过敏,且呈剂量依赖及时间依赖;(3)瑞芬太尼可以引起L4.5脊髓背角磷酸化NR2B表达的增加,右美托咪定以剂量依赖的方式抑制瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。关键词瑞芬太尼;痛觉过敏:磷酸化NR2B;右美托咪定;大鼠3徐州医学院硕士研究生论文1r’n一’■‘●’-●■●oJ-·--EIlecta1111me5、cnan6、sm0l11eXmelletomllCIlne0nremlientaiiil-‘●’●■●op‘‘’●inducellnVDeral2eSlalnaratmodel0lincis7、onalpalnAbstractobjectiveToobservetheeffectsofpreanestheticadministrationofdexmedetomidine(DMED)onremifentanil-inducedhyperalgesiain.aratmodelofincisionalpa8、inandtheexpressionoftheNR2BsubunittyrosinephosphorylationofNMDArec印torintheL4.5spinalcorddorsalhorn.MethodsEighty-fourmaleSDratswererandomlydividedintosevengroups(n_12):Cgroup(contr01),Igroup(incisionalpain),Rgroup(remifentanil+incisionalpain),IDgroup9、(incisionalpain+DMED50pg/kg),RDIgroup(remifentanil+incisionalpain+DMED12.5pg/kg),RD2group(remifentanil+incisionalpain+DMED25I-tg/kg).RD3group(remifentanil+incisionalpain+DMED50pg/kg).IDgroup,RDIgroup,RD2groupandRD3groupwereadministeredsubcutaneouslyDM10、ED0.15ml(dilutedbysaline)attenminutesbeforeanesthesiawithsevoflurane,whileCgroup,IgroupandRgroupwereadministeredsubcutaneouslysalineaccordingly.AllgroupsexceptCgroupwereperformedthemodelofincisionalpain.Methods:A1cmlongincisionwasmadeonskinand
2、太尼诱发的切口周围组织的PWTL值的降低(P>O.05);RD2组、RD3组可以缓解T1(13.75±1.72g,14.03±1.01g)、T2(13.14+-2.21g,14.274-1.33g)、1"3(12.78+-2.75g,14.26+-1.58g)时点瑞芬太尼诱发的大鼠切口周围组织的PMWT值的降低(P3、.05)。(2)Westernblot的结果:与C组(0.06±0.01)相比,I组(O.384-0.03)可以引起术后48h时L4.5脊髓背角磷酸化NR2B表达的增加(P4、0.02)均可抑制由瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。结论在大鼠切口痛模型上,(1)瑞芬太尼可以诱发切口周围组织的痛觉过敏;(2)右美托咪定可以预防瑞芬太尼诱发的痛觉过敏,且呈剂量依赖及时间依赖;(3)瑞芬太尼可以引起L4.5脊髓背角磷酸化NR2B表达的增加,右美托咪定以剂量依赖的方式抑制瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。关键词瑞芬太尼;痛觉过敏:磷酸化NR2B;右美托咪定;大鼠3徐州医学院硕士研究生论文1r’n一’■‘●’-●■●oJ-·--EIlecta1111me5、cnan6、sm0l11eXmelletomllCIlne0nremlientaiiil-‘●’●■●op‘‘’●inducellnVDeral2eSlalnaratmodel0lincis7、onalpalnAbstractobjectiveToobservetheeffectsofpreanestheticadministrationofdexmedetomidine(DMED)onremifentanil-inducedhyperalgesiain.aratmodelofincisionalpa8、inandtheexpressionoftheNR2BsubunittyrosinephosphorylationofNMDArec印torintheL4.5spinalcorddorsalhorn.MethodsEighty-fourmaleSDratswererandomlydividedintosevengroups(n_12):Cgroup(contr01),Igroup(incisionalpain),Rgroup(remifentanil+incisionalpain),IDgroup9、(incisionalpain+DMED50pg/kg),RDIgroup(remifentanil+incisionalpain+DMED12.5pg/kg),RD2group(remifentanil+incisionalpain+DMED25I-tg/kg).RD3group(remifentanil+incisionalpain+DMED50pg/kg).IDgroup,RDIgroup,RD2groupandRD3groupwereadministeredsubcutaneouslyDM10、ED0.15ml(dilutedbysaline)attenminutesbeforeanesthesiawithsevoflurane,whileCgroup,IgroupandRgroupwereadministeredsubcutaneouslysalineaccordingly.AllgroupsexceptCgroupwereperformedthemodelofincisionalpain.Methods:A1cmlongincisionwasmadeonskinand
3、.05)。(2)Westernblot的结果:与C组(0.06±0.01)相比,I组(O.384-0.03)可以引起术后48h时L4.5脊髓背角磷酸化NR2B表达的增加(P4、0.02)均可抑制由瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。结论在大鼠切口痛模型上,(1)瑞芬太尼可以诱发切口周围组织的痛觉过敏;(2)右美托咪定可以预防瑞芬太尼诱发的痛觉过敏,且呈剂量依赖及时间依赖;(3)瑞芬太尼可以引起L4.5脊髓背角磷酸化NR2B表达的增加,右美托咪定以剂量依赖的方式抑制瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。关键词瑞芬太尼;痛觉过敏:磷酸化NR2B;右美托咪定;大鼠3徐州医学院硕士研究生论文1r’n一’■‘●’-●■●oJ-·--EIlecta1111me5、cnan6、sm0l11eXmelletomllCIlne0nremlientaiiil-‘●’●■●op‘‘’●inducellnVDeral2eSlalnaratmodel0lincis7、onalpalnAbstractobjectiveToobservetheeffectsofpreanestheticadministrationofdexmedetomidine(DMED)onremifentanil-inducedhyperalgesiain.aratmodelofincisionalpa8、inandtheexpressionoftheNR2BsubunittyrosinephosphorylationofNMDArec印torintheL4.5spinalcorddorsalhorn.MethodsEighty-fourmaleSDratswererandomlydividedintosevengroups(n_12):Cgroup(contr01),Igroup(incisionalpain),Rgroup(remifentanil+incisionalpain),IDgroup9、(incisionalpain+DMED50pg/kg),RDIgroup(remifentanil+incisionalpain+DMED12.5pg/kg),RD2group(remifentanil+incisionalpain+DMED25I-tg/kg).RD3group(remifentanil+incisionalpain+DMED50pg/kg).IDgroup,RDIgroup,RD2groupandRD3groupwereadministeredsubcutaneouslyDM10、ED0.15ml(dilutedbysaline)attenminutesbeforeanesthesiawithsevoflurane,whileCgroup,IgroupandRgroupwereadministeredsubcutaneouslysalineaccordingly.AllgroupsexceptCgroupwereperformedthemodelofincisionalpain.Methods:A1cmlongincisionwasmadeonskinand
4、0.02)均可抑制由瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。结论在大鼠切口痛模型上,(1)瑞芬太尼可以诱发切口周围组织的痛觉过敏;(2)右美托咪定可以预防瑞芬太尼诱发的痛觉过敏,且呈剂量依赖及时间依赖;(3)瑞芬太尼可以引起L4.5脊髓背角磷酸化NR2B表达的增加,右美托咪定以剂量依赖的方式抑制瑞芬太尼引起的脊髓背角磷酸化NR2B表达的增加。关键词瑞芬太尼;痛觉过敏:磷酸化NR2B;右美托咪定;大鼠3徐州医学院硕士研究生论文1r’n一’■‘●’-●■●oJ-·--EIlecta1111me
5、cnan
6、sm0l11eXmelletomllCIlne0nremlientaiiil-‘●’●■●op‘‘’●inducellnVDeral2eSlalnaratmodel0lincis
7、onalpalnAbstractobjectiveToobservetheeffectsofpreanestheticadministrationofdexmedetomidine(DMED)onremifentanil-inducedhyperalgesiain.aratmodelofincisionalpa
8、inandtheexpressionoftheNR2BsubunittyrosinephosphorylationofNMDArec印torintheL4.5spinalcorddorsalhorn.MethodsEighty-fourmaleSDratswererandomlydividedintosevengroups(n_12):Cgroup(contr01),Igroup(incisionalpain),Rgroup(remifentanil+incisionalpain),IDgroup
9、(incisionalpain+DMED50pg/kg),RDIgroup(remifentanil+incisionalpain+DMED12.5pg/kg),RD2group(remifentanil+incisionalpain+DMED25I-tg/kg).RD3group(remifentanil+incisionalpain+DMED50pg/kg).IDgroup,RDIgroup,RD2groupandRD3groupwereadministeredsubcutaneouslyDM
10、ED0.15ml(dilutedbysaline)attenminutesbeforeanesthesiawithsevoflurane,whileCgroup,IgroupandRgroupwereadministeredsubcutaneouslysalineaccordingly.AllgroupsexceptCgroupwereperformedthemodelofincisionalpain.Methods:A1cmlongincisionwasmadeonskinand
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