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1、2011年4月第8卷第11期·论著·营养不良风险的慢性乙型肝炎患者甲胎蛋白、高尔基体糖蛋白73表达分析翁田波1,谭奕洲2,周桂华3,胡凤玉2,陈秋香4,陈星2,陈冉21.广州市第八人民医院营养科,广东广州510060;2.广州市第八人民医院检验科,广东广州510060;3.广州花都区雅瑶医院外科,广东广州510080;4.广州市第八人民医院肝病科,广东广州510060[摘要]目的:研究应用营养筛查评分简表(NRS2002)评分在甲胎蛋白(AFP)、高尔基体糖蛋白73(GP73)高表达的患者中的应用价值。方法:对206例肝炎患者体重指数(BMI)、白蛋
2、白、AFP、GP73的测定,利用NRS2002评分简表对患者进行评分,将患者分成营养风险组(A组)和非营养风险组(B组),采用统计学方法对A、B组两组患者的AFP、GP73表达进行分析。结果:营养风险组所检测的AFP、GP73高表达率显著高于非营养风险组(P<0.05);营养风险组的CHB、肝硬化、原发性肝癌(PHC)患者AFP、GP73的表达逐渐增加;NRS2002分值越高,AFP、GP73表达亦增高。结论:结合NRS2002评分能更多地将无AFP、GP73高表达的患者被正确区分,从而提高AFP、GP73高表达的检出率。[关键词]慢性活动性肝炎;营
3、养风险筛查(2002);甲胎蛋白;高尔基体糖蛋白73[中图分类号]R512.6[文献标识码]A[文章编号]1673-7210(2011)04(b)-023-03AnalysisoftheExpressionofGP73andAFPinChronicHepatitisBPatientswithMalnutritionRisks1232422WENGTianbo,TANYizhou,ZHOUGuihua,HUFengyu,CHENQiuxiang,CHENXing,CHENRan1.NutritionalDepartment,theEighthPeopl
4、e′sHospitalofGuangzhouCity,Guangzhou510060,China;2.DepartmentofClinicalLaboratory,theEighthPeople′sHospitalofGuangzhouCity,Guangzhou510060,China;3.SurgercalDepartment,YayaoHospitalofHuaduDistrictinGuangzhouCity,Guangzhou510080,China;4.DepartmentofHepatopathy,theEighthPeople'sHo
5、spitalofGuangzhouCity,Guangzhou510060,China[Abstract]Objective:ToinvestigatethevalueofusingNRS2002togradepatientswithhighexpressionofAFPandGP73.Methods:WiththehelpofNRS2002,thepatientswereclassifiedintonutritionriskgroup(A)andnon-nutritiongroup(B)aftertestingtheBMI,albumin,AFP,
6、andGP73of206hepatitispatients.Bymeansofstatisticalmethods,theexpressionofAFPandGP73ofthesetwogroupswillbeanalyzed.Results:TheexpressionrateofAFPandGP73detectedingroupAwereremarkablyhigherthanthatingroupB(P<0.05);theexpressionofAFPandGP73ofthosepatientssufferedfromCHB,cirrhosisa
7、ndPHCintheformergroupincreasedgradually,demonstratingatendencyofhigherexpressionofAFPandGP73withahighergradeinNRS.Conclusion:IntegratedwiththegradingsystemofNRS2002,morepatientswithouthighexpressionofAFPandGP73willbedifferentiatedsoastoimprovethedetectionrateofhighexpressionofA
8、FPandGP73.[Keywords]CHB;Nutritionalriskscreening(NRS20