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1、湖南中医药大学学报2007年6月第27卷第3期14JournalofTCMUniv.ofHunanJun.2007Vol.27No.3开胃进食汤超微配方颗粒对正常小鼠胃肠动力的影响陈斌1,蔡光先25,戴飞跃1,刘柏炎2,龚磊2(1.湖南中医药大学第一附属医院,湖南长沙410007;2.湖南中医药大学,湖南长沙410007)〔摘要〕目的研究开胃进食汤超微配方颗粒对正常小鼠胃排空、小肠推进活动的影响。方法采用开胃进食汤传统汤剂和健胃消食片对照,观察开胃进食汤超微配方的等倍、1/2倍和1/4倍不同剂量对小鼠胃
2、内甲基橙残留率和小肠质量、小肠碳末推进率的影响。结果开胃进食汤超微配方颗粒各组胃内甲基橙残留率较正常组低(P<0.05,P<0.01),等倍和1/2倍剂量组小肠碳末推进率较正常组高(P<0.05,P<0.01),1/2倍剂量组小肠质量较正常组高(P<0.05),而开胃进食汤传统汤剂组与正常组比较,以上指标无差异。结论开胃进食汤超微配方颗粒对正常小鼠具有促进胃肠动力作用,且以1/2倍剂量为优;超微配方颗粒制剂可能与诸相关药物如藿香、木香、丁香等药物挥发油成分作用的关系,从而提高了其传统方剂的药理作用。〔关
3、键词〕开胃进食汤;超微配方颗粒;胃排空;小肠推进;小鼠;木香;丁香;藿香〔中图分类号〕R285.5〔文献标识码〕A〔文章编号〕1000-5633(2007)03-0014-02EffectofUltrafineGranulesofKaiweiJinshiDecoctiononNormalGastricPowerinMiceCHENBin,CAIGuang-xian,DAIFei-yue,LIUBo-yan,GONGLei(FirstAffiliatedHospital,TCMuniversityofHu
4、nan,Changsha,Hunan410007,China)〔Abstract〕ObjectiveTostudytheeffectsofKaiweiJinshidecoctionwiththeultrafineparticleonthenormalgastricevacuatianandsmallintestinalpropulsioninmice.MethodsTheuntrafineandtraditionaldecoctionswerecompared,themethylorangeresidu
5、alrateinstomach,smallintestineweightandsmallintestinecarbonpowderpropulsionrateweremeasuredwiththeisodose,1/2and1/4dosagesofbothultrafineparticleandtraditionaltype.ResultsThemethylorangeresidualrateinstomachinallgroupsofultrafineparticlewerelowerthanthat
6、innormalgroup(P<0.05orP<0.01),thecarbonpowderpropulsionrateinsmallintestinewithsameand1/2dosageswerehigherthanthatinnormalgroup(P<0.05orP<0.01),theweightofsmallintestinewith1/2dosageswasmorethanthatinnormalgroup(P<0.05),while,therewasnodifferencebetweent
7、hetraditionalherbalmedicineandultrafineparticlegroups.ConclusionTheultrafinedecoctioncanimprovethegastrointestinalpower,especiallywith1/2dosagesTtheultrafineparticlepreparationenhancesthepharmacologicalactionowingtopossiblyretainingthecomponentofvolatile
8、oilsuchasClove,AucklandiaeandAgastacherugosa.〔Keywords〕KaiweiJinshidecoctionTultrafineparticleTgastricevacuationTsmallintestinalpropulsionTmiceTacaroidbalsamTchineselilacTageratum〔收稿日期〕2007-02-05〔基金项目〕湖南省科技厅重点项目(04SK1007-1
