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1、《癌症》ChineseJournalofCancer,2008,27(4):359-363359·基础研究·苏拉明对肺腺癌小鼠移植瘤生长的影响及其机制贺兼斌111112,易高众,杨凯,向志,谢茂峰,张平InhibitoryEffectsofSuraminonGrowthofTransplantedLungAdencarcinomainMiceandItsMechanisms111112HEJian-Bin,YIGao-Zhong,YANGKai,XIANGZhi,XIEMao-Feng,ZHANGPing[ABSTRACT]BACKGROUND&OBJECTIVE:Rece
2、ntstudyfoundthatsuramincouldinhibitthegrowthofmalignanttumors,butitsinvivoeffectonlungadenocarcinomahasseldombeenreported.Thisstudywastoinvestigatetheinhibitoryeffectsofsuraminonthegrowthandmetastasisoftransplantedlungadenocarcinomainmice,andexplorethemechanisms.1.怀化市第一人民医院METHODS:Lungaden
3、ocarcinomaLA795cellsweretransplantedinto32呼吸内科,T739mice.Thetumor-bearingmicewererandomizedintocontrolgroup,湖南怀化418000cisplatin(DDP)group,suramingroup,andcombination(suraminplusDDP)2.南华大学附属第一医院group;eachgroupcontained8mice.Differenttreatmentswereservedsince呼吸内科,Day4aftertransplantation.Allm
4、icewerekilled24daysaftertransplantation.湖南衡阳421001Themetastatictumorfocionthelunginmicewerecounted.Theoccurrencerateoflungmetastasisandtheinhibitionrateofmetastaticfociwerecalculated.1.DepartmentofRespiratoryThevolumeandweightoftumorsweremeasured.TheexpressionofepidermalDiseases,growthfact
5、orreceptor(EGFR),P-selectinandproliferatingcellnuclearTheFirstPeople6sHospitalofantigen(PCNA)intumortissuesweredetectedbyimmunhistochemistry.HuaihuaCity,RESULTS:DDPandsuraminusedaloneorincombinationsignificantlyHuaihua,Hunan,418000,inhibitedthegrowthofLA795cellsinmice(P<0.05),withgrowthinh
6、ibitionP.R.Chinaratesof34.9%,23.8%and57.3%,respectively.Theoccurrencerateoflung2.DepartmentofRespiratorymetastasisandthenumberofmetastaticfocionlungsurfacewereDiseases,significantlylowerinsuramingroupandcombinationgroupthaninDDPTheFirstAffliliatedHospital,groupandcontrolgroup(P<0.05).Thepr
7、oteinlevelsofEGFRandP-selectinNanhuaUniversity,weresignificantlyhigherincontrolgroupthaninDDPgroup,suramingroup,Hengyang,Hunan,421001,andcombinationgroup(157.7±6.1vs.130.7±5.9,110.3±5.8,and89.2±P.R.China5.4,P<0.05;134.5±5.7vs.117.9±5.1,96.2±5.4,and78.3±4.5,P<0
