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1、1IntJDevNeurosci.2011Feb;29(1):37-43.Epub2010Oct16.DevelopmentalandmetabolicbrainalterationsinratsexposedtobisphenolAduringgestationandlactation.KunzN,CammEJ,SommE,LodygenskyG,DarbreS,AubertML,HüppiPS,SizonenkoSV,GruetterR.SourceLaboratoryofFunctionalandMetabolicImaging(LIFMET),EcolePolyte
2、chniqueFédéraledeLausanne(EPFL),Lausanne,Switzerland.AbstractInrecentyears,considerableresearchhasfocusedonthebiologicaleffectofendocrine-disruptingchemicals.BisphenolA(BPA)hasbeenimplicatedasanendocrine-disruptingchemical(EDC)duetoitsabilitytomimictheactionofendogenousestrogenichormones.T
3、heaimofthisstudywastoassesstheeffectofperinatalexposuretoBPAoncerebralstructuraldevelopmentandmetabolismafterbirth.BPA(1mg/l)wasadministeredinthedrinkingwaterofpregnantdamsfromday6ofgestationuntilpupweaning.Atpostnatalday20,invivometaboliteconcentrationsintheratpuphippocampusweremeasuredus
4、inghighfieldprotonmagneticresonancespectroscopy.Further,brainwasassessedhistologicallyforgrowth,grossmorphology,glialandneuronaldevelopmentandextentofmyelination.Localizedprotonmagneticresonancespectroscopy((1)HMRS)showedintheBPA-exposedratasignificantincreaseinglutamateconcentrationintheh
5、ippocampusaswellasintheGlu/Aspratio.Interestinglythesetwometabolitesaremetabolicallylinkedtogetherinthemalate-aspartatemetabolicshuttle.QuantitativehistologicalanalysisrevealedthatthedensityofNeuN-positiveneuronsinthehippocampuswasdecreasedintheBPA-treatedoffspringwhencomparedtocontrols.Co
6、nversely,thedensityofGFAP-positiveastrocytesinthecingulumwasincreasedinBPA-treatedoffspring.Inconclusion,exposuretolow-doseBPAduringgestationandlactationleadstosignificantchangesintheGlu/Aspratiointhehippocampus,whichmayreflectimpairedmitochondrialfunctionandalsoresultinneuronalandglialdev
7、elopmentalalterations.2JPhysiolBiochem.2011Jun9.[Epubaheadofprint]Probablegamma-aminobutyricacidinvolvementinbisphenolAeffectatthehypothalamiclevelinadultmalerats.CardosoN,PandolfiM,LavalleJ,CarboneS,PonzoO,ScacchiP,ReynosoR.SourceLaboratoriodeEndocrinología,D
