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1、DOI:10.1158/1078-0432.CCR-07-1257ClinicalSignificanceofEpidermalGrowthFactorReceptorProteinOverexpressionandGeneCopyNumberGainsinProstateCancerThorstenSchlomm,PatrickKirstein,LivIwers,etal.ClinCancerRes2007;13:6579-6584.PublishedonlineNovember15,2007.Upd
2、atedVersionAccessthemostrecentversionofthisarticleat:doi:10.1158/1078-0432.CCR-07-1257CitedArticlesThisarticlecites20articles,9ofwhichyoucanaccessforfreeat:http://clincancerres.aacrjournals.org/content/13/22/6579.full.html#ref-list-1CitingArticlesThisart
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5、rgonJune20,2012Copyright©2007AmericanAssociationforCancerResearchDOI:10.1158/1078-0432.CCR-07-1257HumanCancerBiologyClinicalSignificanceofEpidermalGrowthFactorReceptorProteinOverexpressionandGeneCopyNumberGainsinProstateCancer122233ThorstenSchlomm,Patric
6、kKirstein,LivIwers,BirteDaniel,ThomasSteuber,JochenWalz,33211,3FelixH.K.Chun,AlexanderHaese,JensKollermann,MarkusGraefen,HartwigHuland,222GuidoSauter,RonaldSimon,andAndreasErbersdoblerAbstractPurpose:Theepidermalgrowthfactorreceptor(EGFR)isaproteininvolv
7、edinthetumorprogressionofmanycancertypesandisanimportanttherapeutictarget.Todetermineitsroleinprostatecancer,weanalyzed2,497prostatecancersontheDNAandproteinlevel.ExperimentalDesign:Tissuesamplesfromeachtumorwerebroughtintoatissuemicroarrayandanalyzedbyi
8、mmunohistochemistryandfluorescenceinsituhybridization.AsubsetofcancerswasalsosequencedforEGFRexon18to21mutations.Results:DetectableEGFRexpressionwasfoundin18%ofcancersandwassignificantlyassociatedwithhighgrade,advancedstag
