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1、GModelCANEP-178;No.ofPages7CancerEpidemiologyxxx(2010)xxx–xxxContentslistsavailableatScienceDirectCancerEpidemiologyTheInternationalJournalofCancerEpidemiology,Detection,andPreventionjournalhomepage:www.cancerepidemiology.netDNAmethylationinpre-diagn
2、osticserumsamplesofbreastcancercases:§Resultsofanestedcase–controlstudya,b,*,PaulCairnsca,deeJenniferD.Brooks,RoyE.Shore,CatherineB.Klein,IsaacWirgin,aa,fYelenaAfanasyeva,AnneZeleniuch-JacquotteaDivisionofEpidemiology,DepartmentofEnvironmentalMedicin
3、e,NewYorkUniversitySchoolofMedicine,NewYork,NY10016,UnitedStatesbDepartmentofEpidemiologyandBiostatistics,MemorialSloan-KetteringCancerCenter,NewYork,NY10065,UnitedStatescDepartmentofSurgicalOncologyandPathology,FoxChaseCancerCenter,Philadelphia,PA19
4、111,UnitedStatesdRadiationEffectsResearchFoundation,5-2HijiyamaKoen,Minami-ku,Hiroshima732-0815,JapaneMolecularToxicologyandCarcinogenesisProgram,DepartmentofEnvironmentalMedicine,NewYorkUniversitySchoolofMedicine,Tuxedo,NY10987,UnitedStatesfNewYorkU
5、niversityCancerInstitute,NewYorkUniversitySchoolofMedicine,NewYork,NY10016,UnitedStatesARTICLEINFOABSTRACTArticlehistory:Background:PromotermethylationoftumorsuppressorgenesisafrequentandearlyeventinbreastAccepted8May2010carcinogenesis.Pairedtumortis
6、sueandserumsamplesfromwomenwithbreastcancershowthatpromotermethylationisdetectableinbothsampletypes,withgoodconcordance.ThissuggeststheKeywords:potentialfortheseserummarkerstobeusedforbreastcancerdetection.Methods:ThecurrentstudywasDNAmethylationacas
7、e–controlstudynestedwithintheprospectiveNewYorkUniversityWomen’sHealthStudycohortBreastcanceraimedtoassesstheabilityofpromotermethylationinserumtodetectpre-clinicaldisease.CaseswereEarlydetectionwomenwithbloodsamplescollectedwithinthe6monthspreceding
8、breastcancerdiagnosis(n=50).SerumEachcasewasmatchedto2healthycancer-freecontrolsand1cancer-freecontrolwithahistoryofQMSPbenignbreastdisease(BBD).Results:Promotermethylationanalysisoffourcancer-relatedgenes:—RASSF1A,GSTP1,APCandRARb2,—wasconductedusin
