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1、DNAMethylation,EpigeneticsandMetastasisCancerMetastasis–BiologyandTreatmentVOLUME7SeriesEditorsRichardJ.Ablin,Ph.D.,UniversityofArizonaCollegeofMedicineandTheArizonaCancerCenter,AZ,U.S.A.WenG.Jiang,M.D.,WalesCollegeofMedicine,CardiffUniversity,Cardiff,U.K.AdvisoryEditorialBoardHaroldF.Dvorak,M.D
2、.PhilGold,M.D.,Ph.D.IanR.Hart,Ph.D.HiroshiKobayashi,M.D.,Ph.D.RobertE.Mansel,M.S.,FRCS.MarcMareel,M.D.,Ph.D.TitlespublishedinthisSeriesare:Volume1:CancerMetastasis,MolecularandCellularMechanismsandClinicalIntervention.Editors:WenG.JiangandRobertE.Mansel.ISBN0-7923-6395-7Volume2:GrowthFactorsandR
3、eceptorsinCancerMetastasis.Editors:WenG.Jiang,KunioMatsumotoandToshikazuNakamura.ISBN0-7923-7141-0Volume3:CancerMetastasis-RelatedGenesEditor:DannyR.WelchISBN1-4020-0522-9Volume4:ProteasesandTheirInhibitorsinCancerMetastasisEditor:Jean-MichelFoidartandRuthJ.MuschelISBN1-4020-0923-2Volume5:Microm
4、etastasisEditor:KlausPantelISBN1-4020-1155-5Volume6:BoneMetastasisandMolecularMechanismsEditor:GurmitSinghandWilliamOrrISBN1-4020-1984-XDNAMethylation,EpigeneticsandMetastasisEditedbyManelEstellerSpanishNationalCancerCentre(CNIO),Madrid,SpainAC.I.P.CataloguerecordforthisbookisavailablefromtheLib
5、raryofCongress.ISBN-101-4020-3641-8(HB)SpringerDordrecht,Berlin,Heidelberg,NewYorkISBN-101-4020-3642-6(e-book)SpringerDordrecht,Berlin,Heidelberg,NewYorkISBN-13978-1-4020-3641-5(HB)SpringerDordrecht,Berlin,Heidelberg,NewYorkISBN-13978-1-4020-3642-2(e-book)SpringerDordrecht,Berlin,Heidelberg,NewY
6、orkPublishedbySpringer,P.O.Box17,3300AADordrecht,TheNetherlands.Printedonacid-freepaperAllRightsReserved©2005SpringerNopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorbyanymeans,electronic,mechanical,photocopying,microfilming,recordingorotherwise,withoutwrittenperm
7、issionfromthePublisher,withtheexceptionofanymaterialsuppliedspecificallyforthepurposeofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.PrintedintheNetherlands.TABLEOFCONTENTSListofContributors