Springer.DNA.Methylation.Basic.Mechanisms.Current.Topics.in.Microbiology.and.Immunology.ISBN.3540291148.2006

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1、301CurrentTopicsinMicrobiologyandImmunologyEditorsR.W.Compans,Atlanta/GeorgiaM.D.Cooper,Birmingham/AlabamaT.Honjo,Kyoto·H.Koprowski,Philadelphia/PennsylvaniaF.Melchers,Basel·M.B.A.Oldstone,LaJolla/CaliforniaS.Olsnes,Oslo·M.Potter,Bethesda/MarylandP.K.Vogt,LaJolla/California·H.Wagner,MunichW.Doerfl

2、erandP.Böhm(Eds.)DNAMethylation:BasicMechanismsWith24Figuresand3Tables123WalterDoerfler,Prof.Dr.WalterDoerfler,Prof.Dr.PetraBöhmUniversitätErlangenUniversitätzuKölnInstitutfürKlinischeInstitutfürGenetikundMolekulareVirologieZülpicherStr.47Schlossgarten450674Köln91054ErlangenGermanyGermanye-mail:wal

3、ter.doerfler@uni-koeln.de,e-mail:p.boehm@uni-koeln.dewalter.doerfler@viro.med.uni-erlangen.deCoverillustration:MethylationProfileofIntegratedAdenovirusType12DNAInthegenomeoftheAd12-transformedhamstercelllineTR12,onecopyofAd12DNA(greenline)andafragmentofabout3.9kbfromtherightterminus(redline)oftheAd1

4、2genomearechromosomallyintegrated(fluorescentinsituhybridization,upperleftcornerofillustration).TheintegratedviralsequencehasremainedpracticallyidenticalwiththesequenceofthevirionDNA.All1634CpG´sinthisdenovomethylatedviralinserthavebeeninvestigatedfortheirmethylationstatusbybisulfitesequencing.Asma

5、llsegmentofthesedataisshownatthebottomofthegraph.OpensymbolsindicateunmethylatedCpG´s,closedsymbolsmethylated5-mCpGdinucleotides.ThisfigurehasbeenpreparedbyNorbertHochstein,InstituteforClinicalandMolecularVirol-ogy,ErlangenUniversityandisbasedondatafromamanuscriptinpreparation(N.Hochstein,I.Muizni

6、eks,H.Brondke,W.Doerfler).LibraryofCongressCatalogNumber72-152360ISSN0070-217XISBN-103-540-29114-8SpringerBerlinHeidelbergNewYorkISBN-13978-3-540-29114-5SpringerBerlinHeidelbergNewYorkThisworkissubjecttocopyright.Allrightsreserved,whetherthewholeorpartofthematerialisconcerned,specificallytherightso

7、ftranslation,reprinting,reuseofillustrations,recitation,broadcasting,reproductiononmicrofilmorinanyotherway,andstorageindatabanks.Dupli-cationofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheGermanCo