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1、DOI10.3349/ymj.2010.51.4.562OriginalArticlepISSN:0513-5796,eISSN:1976-2437YonseiMedJ51(4):562-568,2010TreatmentandOutcomesofMelanomainAcralLocationinKoreanPatientsMiRyungRoh,JihyunKim,andKeeYangChungDepartmentofDermatologyandCutaneousBiologyResearchInstitute,YonseiUniversityCollegeofMedicine,S
2、eoul,Korea.Received:May26,2009Purpose:Aretrospectivestudywasconductedtoreviewthetreatmentandout-Revised:October19,2009comesofmainlymelanomasinacrallocationinasingleinstitutioninKorea,andAccepted:November4,2009toevaluatetheprognosticsignificanceofanatomiclocationsofthetumor.MaterialsCorrespondi
3、ngauthor:Dr.KeeYangChung,andMethods:Aretrospectivereviewwascompletedon40patientsbetweenDepartmentofDermatologyandCutaneous2001and2006toobtainpertinentdemographicdata,tumordata,treatmentcharac-BiologyResearchInstitute,YonseiUniversityteristics,andfollow-updata.Results:Fortymelanomapatientswerei
4、dentifiedCollegeofMedicine,250Seongsan-ro,andanalyzed.Ofthese,18weremaleand22werefemalepatientsandthemeanSeodaemun-gu,Seoul120-752,Korea.ageatthetimeofdiagnosiswas55.9years.Ofthetumors,65%werelocatedonTel:82-2-2228-2080,Fax:82-2-393-9157thehandsandfeetwithacrallentiginousmelanomabeingthemostco
5、mmonE-mail:kychung@yuhs.achistologicalsubtype.Univariateanalysisfortheoverallmelanomasurvivalrevealedthatthethicknessofthetumorandtheclinicalstagehaveprognosticsignificances.∙Theauthorshavenofinancialconflictsofinterest.Themostsignificantfactorasanalyzedbyamultivariateanalysiswasshowntobethead
6、vancedclinicalstage.Acralmelanomasdidnotshowstatisticallysignificantdifferencesintheageatdiagnosis,thicknessofthetumor,stage,ulceration,andsurvivalratescomparedtonon-acralmelanomas.Therewasalsonosignificantdifferenceinthesurvivalratebetweenthepatientstreatedbyamputationversuswidelocalexcisioni
7、nacralmelanomas.Conclusion:InKoreanmelanomapatients,thicknessandadvancedstagesaresignificantfactorsforpoorerprognosis.However,thelocationofmelanomadidnothaveasignificantprognosticvalue.Intreatingthemelanomasinacrallocation,localwideexci
