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1、ActaPhysiologicaSinica,ZHUGuo-Qingetal:NitricOxideandChronicHeartFailureFebruary25,2004,56(1):47-5347http://www.actaps.com.cnResearchPaperReducednitricoxideintherostralventrolateralmedullaenhancescardiacsympatheticafferentreflexinratswithchronicheartfailureZHUGuo-Qing1,*,GAOXing-Ya1,ZHA
2、NGFeng1,WANGWei21DepartmentofPhysiology,NanjingMedicalUniversity,Najing210029,China;2DepartmentofPhysiologyandBiophysics,UniversityofNebraskaCollegeofMedicine,Omaha,NE68198-4575,USAAbstract:Thepurposeofthisstudywastodeterminetheeffectofnitricoxide(NO)intherostralventrolateralmedulla(RVL
3、M)onthecentralintegrationofthecardiacsympatheticafferentreflex(CSAR)innormalratsandinratswithcoronaryligation-inducedchronicheartfailure(CHF).Underα-chloraloseandurethaneanesthesia,meanarterialpressure,heartrateandrenalsympatheticnerveactivity(RSNA)wererecordedatbaselineandduringelicita
4、tionoftheCSARevokedbyelectricalstimulationofthecardiacafferentsympatheticnervesinsino-aorticdenervatedandcervicalvagotomizedrats.AcannulawasinsertedintotheleftRVLMformicroinjectionofNOsynthaseinhibitor,S-methyl-L-thiocitruline(MeTC)orNOdonor,S-nitroso-N-acetyl-penicil-lamine(SNAP).TheCS
5、ARwastestedbyelectricalstimulation(5,10,20and30Hzat10Vfor1ms)oftheafferentcardiacsympatheticnerves.Itwasobservedthat(1)theresponsesofRSNAtostimulationwereenhancedinratswithCHF;(2)MeTC(80nmol)potentiatedtheresponsesofRSNAtostimulationinshamratsbutnotinratswithCHF;(3)SNAP(50nmol)depressed
6、theenhancedRSNAresponsetostimulationinCHFratsbuthadnoeffectinshamrats;and(4)MeTCincreasedthebaselineRSNAandMAPonlyinshamrats,butSNAPinhibitedthebaselineRSNAandMAPinbothshamandCHFrats.TheseresultsindicatethatreductanceofNOintheRVLMisinvolvedintheaugmentationofCSARinCHFrats.Keywords:cardi
7、ovascularphysiology;nitricoxide;heartfailure;cardiacsympatheticafferentreflex;rostralventrolateralmedulla1,*1121,210029;2,,NE68198-4575,:(rostralventrolateralmedulla,RVLM)(NO)(chronicheartfailure,CHF)(cardiacsympatheticafferentreflex,CSAR),CHFSD,(renalsympatheticnerveactivity,R
