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1、NEURALREGENERATIONRESEARCHVolume8,Issue2,January2013www.nrronline.orgdoi:10.3969/j.issn.1673-5374.2013.02.007[http://www.nrronline.org;http://www.sjzsyj.org]ZhangCX,HamadaT.Sexdifferencesinestrogenreceptorpromoterexpressionintheareapostrema.NeuralRegenRes.2013;8(2):149-155.
2、Sexdifferencesinestrogenreceptorpromoterexpressionintheareapostrema*☆○12ChunxiaoZhang,TomohiroHamada1DepartmentofPhysiology,NormanBethuneCollegeofMedicine,JilinUniversity,Changchun130021,JilinProvince,China2DepartmentofPhysiology,NipponMedicalSchool,Tokyo113-8602,JapanAbstr
3、actEstrogenreceptorαiswidelydistributedintheratbrain,butthetissue-ortarget-specificityoftheChunxiaoZhang☆,Ph.D.,Associateprofessor.estrogenreceptorαgenepromotersremainsunknown.Inthepresentstudy,weusedtransgenicratsexpressingenhancedgreenfluorescentproteinunderthecontrolofth
4、eestrogenreceptorα0/BCorrespondingauthor:promotertoexamineexpressiondrivenbythispromoterintwosignificantnucleithatregulateTomohiroHamada,DepartmentofPhysiology,cardiovascularactivity,theareapostremaandthenucleustractussolitarius.ImmunohistochemistryNipponMedicalSchool,showe
5、dthatenhancedgreenfluorescentprotein-labeledcellsweredistributedintheareapostremaTokyo113-8602,Japan,hamada@nms.ac.jp.andthenucleustractussolitariusofbothfemaleandmaletransgenicrats,andaneuralnetworkofenhancedgreenfluorescentprotein-positivefiberswasseenbetweentheareapostre
6、maandtheReceived:2012-06-01nucleustractussolitarius.Thenumberofenhancedgreenfluorescentprotein-labeledcellsintheAccepted:2012-11-05(N20111215001/YJ)areapostremaoffemaleratswassignificantlyhigherthaninthemales,butnosignificantdifferencewasfoundinthenumberofenhancedgreenfluor
7、escentprotein-labeledcellsinthenucleustractussolitarius.Thesexdifferencesinthenumberofenhancedgreenfluorescentprotein-labeledcellsintheareapostremawasnotaffectedafterovariectomyor17β-estradiolbenzoatetreatmentinadultrats.Ourresultssuggestthattheeffectsofestrogenintheareapos
8、tremaarerelatedtotheexpressionofestrogenreceptorαunderthecontrolofthe0/Bpromoter,a
