睾酮诱导骨髓巨噬细胞凋亡并增加杜氏利什曼原虫对巨噬细胞的侵袭力

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1、山西医科大学硕士学位论文睾酮诱导骨髓巨噬细胞凋亡并增加杜氏利什曼原虫对巨噬细胞的侵袭力姓名：刘立民申请学位级别：硕士专业：病原生物学指导教师：乔中东2002.5.6艮；7锅晦箩性j彬蚺¨砻7广芗和西矽乏瘫菩专{侈{f，矽山≯撒强印蒯一向譬U啶认知心嗲从季弘石绎瞄、毫)荐能I司：狙继例色謦缝挫疑哆毕竺弥锣藐徽新形p呔秀厥椭彬雠Ⅳ统”r。丫“，、，彤一～●厶文＼∞榔罄ShanxiMedicalUniversityAcademicDissertationforMaster_——_————●—————————-————_—————————-—————————————————————————

2、———一一AbbreviationsRTARBMMbpca2+hDEPCDNAEBEDTAFCMFCSgGPCRTLCMLPS上．DMreversetranscriptaseandrogenreceptorBoneMarrowderived—Macrophagebasepair(s)ionizedcalciumhourdiethylpyrocarbonatedeoxyribonucleicacidethidiumbromideethylenediaminetetraaceticacidflowcytometerfetalcalfsei3．1mgramorgravityG·-prot

3、ein·-coupledreceptorsfortestosteroneL929eellconditionedmediumlipopolysaccharideLeishmaniadonovanfmole／LShanxiMedicaJIjniversityAcademicI)issertalion}0rMasterM—CSFmMmRNAOD260pBSPCDpCRPIRNARNaseSDSTB毯TeE2TE锵．伐1’isUVHREmacrophage&monocyte—colonystimulatingfactormillimole／Lmessengerribonucleicacid

4、opticaldensityat260nmphosphate—bufferedsalineProgrammedCellDeathPolymeraseChainReactionpropidiumiodideribonucleicacidribonucleasesodiumdodecylsulfateTris／borateelectrophoresis(buffer)testosteronel7．B—estradioltumornecrosisfactor-atris(hydroxymethyl)aminomethaneultra．violethormoneresponseelemen

5、tShanxiMedicalUniversityAcademicDissertationIbrMasterAbstractSexualdimorphismintheimmunesystemsoffemalesandmalesiswellestablished．Thesex—dependentdifferencesbetweenfemaleandmalenormalandautoimmuneresponsesisgenerallyattributedtotheinfluenceofestrogensandandrogenseventhoughlimitedinformationhas

6、beenreportedonthespecificmechanismsofsteroidsonimmunecells．Ingeneraltermsfemaleshaveagreaterresistancetovariousbacterialandviralinfectionsthanmaleswiththeirotherenhancedimmunecapabilitiesmightcontributetotheirhighersurvivalrates．Macrophagesareversatilecellswhoseactivitiesareprogrammedbyenviron

7、mentalsignalsTheevidenceaccumulatedtodatesupportsthepostulatethatsexhormonesprofoundlyinfluencehostdefensebycontrollingtheabilityofmacrophagestoparticipateinimmuneresponses．Inthepresentstudy,weinvestigatedthedirecteffectofsexhormonesonm