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时间:2019-05-14
《合宫颈活检对诊断宫颈鳞状上皮病变的临床价值》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、肿瘤2012年4月第32卷第4期TUMORVol.32,April2012www.tumorsci.org291DOI:10.3781/j.issn.1109-0721.2012.04.012Copyright©2012byTUMOR临床研究·ClinicalResearch液基薄层细胞学检测联合宫颈活检对诊断宫颈鳞状上皮病变的临床价值赵瑞皎,石曼丽,张家兴,孔令非河南省人民医院病理科,郑州450003[摘要]目的:探讨液基薄层细胞学检测(liquid-basedthinPrepcytologytest,TCT)联合宫颈活检对诊断宫颈鳞状上皮病变的临床价值。方法:应用TCT
2、对30350例受检者进行宫颈细胞学检查,细胞学检查结果为鳞状上皮异常者,进行阴道镜活检及病理检查。结果:TCT检出鳞状上皮异常者1824例(6.01%),其中无明确意义的不典型鳞状细胞(atypicalsquamouscellsofundeterminedsignificance,ASC-US)1423例,不除外高度鳞状上皮病变的不典型鳞状细胞(atypicalsquamouscellscannotexcludehighgradeintraepitheliallesion,ASC-H)214例,低度鳞状上皮内病变(lowgradesquamousintraepithelial
3、lesion,LSIL)92例,高度鳞状上皮内病变(highgradesquamousintraepitheliallesion,HSIL)80例,鳞状细胞癌(squamouscellcarcinoma,SCC)15例。与活检病理检测结果相比,1423例ASC-US中,宫颈上皮内瘤样病变-I级(gradeIcervicalintraepithelialneoplasia,CIN-I)202例、CIN-Ⅱ和CIN-Ⅲ22例、SCC1例;214例ASC-H中,CIN-I12例、CIN-Ⅱ和CIN-Ⅲ101例、SCC5例;LSIL、HSIL及SCC组中与组织病理检测结果的符合率分
4、别为63.04%(58/92)、81.25%(65/80)及100%(15/15),SCC组和HSIL组的组织学符合率高于LSIL组(P<0.01)。结论:TCT与阴道镜活检病理检测结果有较高的符合率,二者联合能提高宫颈癌前病变及癌变的检出率。[关键词]宫颈肿瘤;宫颈上皮内瘤样病变;人体乳头状瘤病毒;活组织检查;液基薄层细胞学检测[中图分类号]R737.33[文献标志码]A[文章编号]1000-7431(2012)04-0291-04Clinicalvalueofliquid-basedthinPrepcytologytestandcervicalbiopsyinthedi
5、agnosisofcervicalsquamousepitheliallesionsZHAORui-jiao,SHIMan-li,ZHANGJia-xing,KONGLing-feiDepartmentofPathology,HenanProvincialPeople’sHospital,Zhengzhou450003,China[ABSTRACT]Objective:Toinvestigatetheclinicalvalueofliquid-basedthinPrepcytologytest(TCT)andcervicalbiopsyinthediagnosisofcer
6、vicalsquamousepitheliallesions.Methods:TCTwasperformedin30350subjects,andthecolposcopy-directedbiopsyandhistopathologicalexaminationwereperformedwhentheTCTrevealedabnormalcervicalsquamousepitheliallesions.Results:TCTresultsrevealedthat1824(6.01%)caseshadabnormalcervicalsquamousepithelialle
7、sions,including1423casesofatypi-calsquamouscellsofundeterminedsignificance(ASC-US),214casesofatypicalsquamouscellscan-notexcludehighgradeintraepitheliallesions(ASC-H),92casesoflowgradesquamousintraepitheliallesions(LSIL),80casesofhighgradesquamousintraepitheli
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