欢迎来到天天文库
浏览记录
ID:36665093
大小:768.67 KB
页数:43页
时间:2019-05-13
《马来酸罗格列酮及辛伐他汀对胰岛素抵抗患者血清C反应蛋白水平的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、山西医科大学硕士学位论文马来酸罗格列酮及辛伐他汀对胰岛素抵抗患者血清C反应蛋白水平的影响姓名:赵乃倩申请学位级别:硕士专业:内分泌代谢指导教师:张志利2003.5.28些盟匡抖厶堂亟士鲎垃迨塞马来酸罗格列酮及辛伐他汀对胰岛素抵抗患者血清C反应蛋白水平的影响研究生:导师:赵乃倩张志利摘要目的:研究马来酸罗格列酮及辛伐他汀对胰岛素抵抗患者血清C反应蛋白水平(CRP)的影响。方法:按空腹胰岛素>16.8眦u/L确诊胰岛素抵抗患者5l例,根据随机配伍组设计的原则按1:l:1等含量分为三组,马来酸罗格列酮组17例,辛伐他汀组17例,对照组17例。马来酸罗格列酮组每曰服马来酸罗格列酮4
2、mg,辛伐他汀组每日服辛伐他汀20mg,对照组无特殊处理,共观察14天。试验前后采血测白细胞介素一6(IL一6)、肿瘤坏死因子一Q出蝤廷抖厶堂亟±。星:位论室(TNF—Q)和CRP。结果:cRP在马来酸罗格列酮组、辛伐他汀组均较治疗前下降,在对照组略有升高。经配对t检验,t值分别为5.430、—玉8磐和Q出挖fP《姻舛—妒娘o{善和节;9珙‰r多重比较q一检验显示,马来酸罗格列酮组与辛伐他汀组比较,p<0.05,差异有显著性。三组试验前后IL.6、n晒.Q比较无统计学意义。结论:对胰岛素抵抗患者马来酸罗格列酮和辛伐他汀在14天内可降低CRP水平,马来酸罗格列酮降低cRP作用
3、可能要强于辛伐他汀。[关键词]马来酸罗格列酮辛伐他汀胰岛素抵抗C反应蛋白出西医型厶堂砸±。羔位途塞EfrectsofrosiglitazonemaleateandsimVastatinonfastingsemmC-reactivepmteininpatientswithinsulinreSlStanCeAbstractobjective:ToinveStigatetIleeffectsofrosiglitazonemaleateaIldsimvastatinonfastingserumC—reactiVeproteininpatientswiminsulinresistan
4、ceMethods:Thestudywasarafldomizedblockdesignincluding5lsu均ectswithinsulinresistance(fastingsemminsulin>16.8“U/L).Theyweredividedinto3铲oups,i.emsiglitazonemaleate(R)(17cases),simVastatin(S)(17cases‘)alldcomrol(C)(17caSes)gfoups.ThesubjectsofgroupRweretre砒edwi也rosi酉itazonemaleate4mgdaily.The
5、subjectsof黟。印SweregiVensimVastatin20mgdaily,andgroupCwerenottrea肥d.Theyweref01lowed14days3出鳕廷抖厶堂——————亟±鐾位论童Fastingseruminterleukin·6(IL一6),tumornecmsisfactor‘Q(TNF-Q)aIldCRPweremeasuredatday0andatday15,ResuIts:Att}leendofthestudy,log(CRP)leVelswere一.—_s培n蛳啪吗越∞w乒h莒∞q“o—弭妇m占豁e轴蟾oata,粕出m洱《}一
6、(CRP)levelwasslightlyhi曲eringroupCusingttest(t=5.430,p<0.00l,t=2.827,p<0.012,andt20.122,p=O.904,reSpectiVely).Atday15,log(CRP)wassignificantlylowerinpatientsonmsiglitazonemaleatewhencomparedwithsimvastatin(p7、iglit鼬ronemaleateandsimvastatinsignificantlydecreasedleVelsofCRPinpatientswithinsulinresistance,whilstmee岱蛾ofsimvastalinwaslikelysmallercomparedwitll吐latofrosiglit鼬ronemaleateKeywords:Rosigiita删lemaleateSimVastatinInsulinresistanceC—reactiVeprotein山盟廷抖厶堂——一——亟
7、iglit鼬ronemaleateandsimvastatinsignificantlydecreasedleVelsofCRPinpatientswithinsulinresistance,whilstmee岱蛾ofsimvastalinwaslikelysmallercomparedwitll吐latofrosiglit鼬ronemaleateKeywords:Rosigiita删lemaleateSimVastatinInsulinresistanceC—reactiVeprotein山盟廷抖厶堂——一——亟
此文档下载收益归作者所有