VVC患者阴道局部免疫状态及发病相关因素研究

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1、上海交通大学硕士学位论文VVC患者阴道局部免疫状态及发病相关因素研究姓名：王文申请学位级别：硕士专业：妇产科学指导教师：狄文20070501VVC常混合细菌感染。（4）假丝酵母菌培养的阳性率为8.5％，其中白假丝酵母菌是VVC的主要病原体占83.83％，非白假丝酵母菌占16.17％。（5）对阴道冲洗液进行IL－2、IL－4、HD5、HBD1、HBD2检测发现，两组间IL－2、IL－4比较无差异（P>0.05）；而HD5、HBD1、HBD2的含量VVC组明显高于正常女性组，两组间差异显著（P<0.05）。结论：VVC是女性常见的外阴阴道炎，在育龄期妇女该病的发生与学历、对妇

2、科感染的了解程度、妇科炎症病史、卫生习惯、性生活情况、药物应用情况无明显关系。非白假丝酵母菌感染引起的VVC应受到重视，必要时应进行阴道分泌物细菌培养。人类防御素的作用可能与VVC的发病密切相关。关键词：外阴阴道假丝酵母菌病，局部免疫，人类防御素ＡSTUDYONVAGINALLOCALIMMUNESTATEANDTHECORRELATEDPATHOGENETICFACTORSOFVULVOVAGINALCANDIDIASIS(VVC)ABSTRACTObjective:AccordingtocomparingVVCpatientswithnormalwoman,toinv

3、estigatethecorrelatedfactors,tostudyonthevaginallocalimmunestate,tofindtherelationshipofVVCandthelocalimmune,sothattoimprovetheeffectofpreventionandtherapy.Method:CasecontrolstudywasusedtocompareGroupVVCwithGroupnormalwomen.Allofthewemonfilledinthequestionnaires.Routinexamination、PHexamin

4、ationandbacterialcultureweredoneonthevaginaldischarge.TodetectandanalyzecytokinesonthevaginallavagewithELISA..Routinexamination、PHexaminationandbacterialcultureweredoneonthevaginaldischargeofthecensuswemon.Result:(1)Outcomeofthequestionnaires:thereisnosignificantdifferencebetweentwogroups

5、ineducationalbackground、theknowingofgynecologicinfection、thehistoryofgynecologicinfection、healthyhabit、sexullife、usingmedicin(P>0.05);theincidenceofchroniccervicitisinGroupnormalwemonwashigherthaninGroupVVC(P>0.05).(2)ThereisnodifferencebetweenGroupnormalwemonandGroupVVCinvaginalPH(P>0.05

6、).(3)Regardbacterialcultureasthediagnosticcritera,detectionrateofVVCbyvaginaldischargeroutineexaminationwas71.67%;VVCwasoftencomplicatedwithbacteria.(4)Thepositiverateofcandidacultureis8.5%;therateofcandidaalbicansis83.83%,therateofnon-candidaalbicansis16.17%.(5)TodetectIL－2、IL－4、HD5、HBD1

7、、HBD2invaginallavage，therewasnodifferencebetweentwogroupsinIL－2、IL－4（P>0.05）,butthecontentofHD5、HBD1、HBD2inGroupVVCwerehigherthanGroupnormalweman(P<0.05)Conclusion:VVCisthecommonvulvovaginitis.TherewasonsignificantcorrelationbetweenincidenceofVVCandeducationalbackgr