基于结构频谱的蛋白质三维结构研究

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1、分类号：——密级：——单位代码：!Q鲤Z学号：2QQ垒!Q!18西北大学博士学位论文指导教师周塑全专业技术职务筮攮学科(专业)一一盐簋查噬盐鱼墨途答辩日期学位授予日期二oo七年六月AStudyOnThreeDimensionalProteinStructureBasedOnStructuralSpectrumABSTRACTOneoftheaimsofHm'nanGg'nomeProjectistoelucidatethestructures，functionsandinternalinteractionsofaboutahundredthousandprotein

2、sofhumanbeingaswellastheirrelationswithvariousdiseases．n把threedimaasionaistructureofproteiniscloserelatedwithit’sfunction,thusthestudyofproteinstructureisthecoreissueofProtcomics．However,comparingthree-dimensionalstructuresbe

3、嘶嘞proteinsisataskofcomputergraphics．Thcdissertationfocuseson

4、keytechniquesofsuchcomparison,whichisdoneinbothglobalandlocalgcnseandproposeseffluentmethodsinmulti-levelcomparisonofprotein’Sspacialslxucturvs．11leresearchworks黜asfollows：1．Wilh盐integrationofdatamining,computergraphicsanddigitalimageprocessing,thedissertationfirstexaminesthedatanormal

5、izationofprotein’sthreedimensionalm-uctures，thmfeatureextractionandthemulti．1evelcomparisonofthreedimensionalstruct甜es,andfinallyproposesamechanismofcan了ingouttheprotein'sspacialcomparisoninbothglobalandlocalsense．2．Visualizationofprotein'sthree-dimensionalstructure．3．Bymeansofanalyzin

6、gtheprotein'swincipalcomponentwithsecond-ordermoments，establishthethree-dimeusionalunifiedcoordinatesofproteins．Underthecoordinates,implementwavelettransformtobuildthemulti．scalespectrumofthespatials仃ucturethatrepresentsprotein'sa-carbondistanceanditscoordinatesequencerespectively．Thus

7、,theprotein'smulti-levelfeaturesareextracted．4．Utilizethegreyincidencetheorytocomparetheprotein'sspatialstructureandthenanalyzetheprotein'sstructuralspectrum,whichcomprehensivelydescribethesimilaritiesoftheprotdn'sspacialstnlcturesinmulti-scales翻1辩．5．Implementfractalanalysistothesimila

8、rifiesoftheprotein'sspacialstructurespectrum,whichshowsanotherwayofmulti．1evelcomparisonbetweenproteins．ThisresearchisfundedpartlybytheNa6伽lalNaturalScienceFoundationofChinaandfullybydedicatedresearchplanofShaanxieducationbureau，Keywords：structuralspectrum，unifiedcoordinates，greyinci