禹州漏芦中抗肿瘤成分α三联噻吩的提取工艺研究

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1、河北科技大学硕士学位论文禹州漏芦中抗肿瘤成分α-三联噻吩的提取工艺研究姓名：段洪良申请学位级别：硕士专业：生物化工指导教师：杨文玲20090501河北科技大学硕士学位论文AbstractTheanti-tUITlOringredienta-terthienyl(Q·T)wasextractedbysupercritica]C02fromRadixEchinopsiswhichpurchasedfromanhuiProvincemaozhouCitydrugcompany．ItWascomparedwi也thetraditionalsolven

2、t—extractionprocess．Throughtheexperiments，theeffectsofdifferentprocessingconditiononpurity．andyieldofOr-TweresmdieAsystematically，andthesuitabletechnologicalconditionsweredetermined．Throughthesinglefactorexperiment,theextractingpressure，theextractingtemperature，theextractin

3、gtime，theflowrateofcarbondioxidejandtheamountofentrainerusedwerestudiedduringtheprocessoftheextractionofa-TbysupercriticalC02．Theoptimumparameterswereobtainedbyorthogonaltestasfollows：theextractingpressureWas25MPa,theextractingtemperaturewas45"C，theextractingtimeW&S90min．，t

4、heflo,a+rateofCO：was20kg-h～÷andtheratioofthequantity．ofe也v】alcohol(entrainer)tOthatofRadixEchinopsispowderWas7：10．Theyieldofa-Twasachieved95．36％attheaboveoptimumconditions，ThesuitableextractionsolventWasselectedfromfourorganicsolvents：ethy．1alcohol：acetone．ethylacetateandbe

5、nzine．Theoptimumparameterswereobtainedbyorthogonaltestasfollows：theratioofthequantityofacetonetOthatofRadixEchinopsispowderWaS4：1，theextractiontemperatureWas45"C，theextractiontimeWas4h，nleyieldofa·TWaSachieved74．18％。ComparedwiththcPh3’；icalpropertyandtheoutwardappearanceofa

6、-TwhichobtainedbythesupercriticalC02extractionmethodandthesolvent—extractionprocess．ThelusterofproductofwhichobtainedbythesupercriticalC02extractionmethodmuchmorebetterthanthatofthewhichobtainedbythesolvent—extractionprocess．Itprovidedthesuitablereferencefor0【．T也eextractind

7、ustrializati012．TheproducttaskedfromsupercriticalC02extractionwaspurifiedbythesilicagelcolumnchromatographyonthefll／'ther．Tbepurityofa-TobtainedWas85．30％．theextractionpercentofa-TWas82．79％．而eeffectsofdifferenttechnologicalparameteron．purityandyieldofa-Twerestudiedwithemphas

8、is．nleoptimumparameterswereobtainedbyorthogonaltestaSfollow：Thee

9、uentwasthemixsolu