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1、无症状脑梗死患者血清高敏C反应蛋白和肿瘤坏死因子-α水平的变化及其临床意义生箜鲞第2期ChinJCerebrovcscDis(ElectrVers),Atrril2008.Vo1.2.No.2无症状脑梗死患者血清高敏C反应蛋白和肿瘤坏死因子-0【水平的变化及其临床意义李林文,王峰,王元业,胡屹伟摘要目的:探讨无症状脑梗死(SCI)患者血清高敏C反应蛋白(hs.CRP),肿瘤坏死因子一ot(TNF—ot)水平的变化及其在发病机制中的作用.方法:分别检测40例SCI,40例脑梗死(cI)患者,40例健康对照者血清hs-CRP和TNF
2、—ot含量.结果:SCI组和cI组hs—CRP含量分别为(8.86±0.96)和(16.32±1.88)mg/L,均显着高于对照组的(1.69±0.56)mg/L(P<0.01),cI组hs—CRP含量亦显着高于SCI组(P<0.05);SCI组和cI组TNF—ot含量分别为(1.92±0.73)和(2.56±0.91)ng/mL,显着高于对照组的(1.13±0.42)ng/mL(P<0.01),cI组TNF—ot含量亦显着高于SCI组(P<0.05).在SCI患者中,梗死灶数>2个组(n=19)h
3、s-CRP为(9.45±0.97)mg/L,显着高于梗死灶数≤2个组(n=17)的(7.21±0.75)mg/L(P<0.01),两组TNF—ot含量分别为(1.97±0.83)和(1.66±0.56)ng/mL,无显着差异.血压测定值越高,腔隙性梗死灶数量越多,未服降压药者梗死灶数量显着多于正规降压治疗者(P<0.05).结论:炎症过程参与了脑小血管病变;hs—CRP和TNF—ot水平与脑缺血程度,神经功能缺损程度以及脑的小血管病变范围密切相关.高血压是腔隙性SCI最常见的病因,未降压治疗的重度高血压更易引起多发性
4、腔隙性脑梗死.从预防再发的角度看,对SCI应尽早采取积极有效的治疗措施,高血压患者应尽早正规服用降压药.关键词脑梗死;C-反应蛋白;肿瘤坏死因子一otChangesofSerumHigh-SemitivityC—ReactiveProteinandTuinorNecrosisFactor-~tand1heirClinicalSignificanceinPatientswithSilentCerebralInfarctionLin—WenLi,FengWang,Yuan-YeWang,Yi—WeiHuDepartmentofNeu
5、rology,ZaozhuangOtyHospital,Zaozhuang277102,ChinaCorrespondingAuthor."Lin—WenLi'AbstractObjective:Toinvestigatethechangesofserumhigh-sensitivityC-.reactiveprotein(hs.-CRP1andtumornecrosisfactor—oL(TNF—oL1levelsinpatientswithsilentcerebralinfarction(sci)andtheirrolesi
6、npathogenesis.thods:1elevelsofser1.wflhs—CRPandTNF—oLinpa-tientswithSCI(nz40),cerebralinfarction(CI1(n=401andhealthycontrols(n=401weremeasuredrespectively.Results:1helevelsOfhS—CRPinbothSCIandCIgroupswere8.86±0.96and16.32±1.88呲,respectively.1heYweresignificantlyhighe
7、rthan1.69±0.56mg/Linthecontrolgro(尸<0.011.ThelevelsofhS—CRPintheCIgroupwerealsosignifi—cantlyhigherthanthoseintheSCIgro(P<0.05);thelevelsofTNF—oLinbothSCIandCIgroupswere1.92±0.73and2.564-_0.91ng/n~.respectively.qheyweresignificantlyhigherthan1.13±0.42nz_/mLinth
8、econtrolgro(P<0.01).1helevelsofTNF一仪intheCIgroupwerealsosignificantlyhigherthanthoseintheSCIgro坤(P<0.05).Thenumbersofinfarcti
