中青年无症状脑梗死患者血清高敏C-反应蛋白、同型半胱氨酸、尿酸水平与颈动脉内-中膜厚度的关系.pdf

《中青年无症状脑梗死患者血清高敏C-反应蛋白、同型半胱氨酸、尿酸水平与颈动脉内-中膜厚度的关系.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、临床神经病学杂志2014年第27卷第4期·265·论著·中青年无症状脑梗死患者血清高敏C一反应蛋白、同型半胱氨酸、尿酸水平与颈动脉内一中膜厚度的关系张艳茹，张丽敏，曹向辉，王红梅，贺永贵【摘要】目的探讨中青年无症状脑梗死(SCI)患者血清高敏c一反应蛋白(hsCRP)、同型半胱氨酸(Hcy)、尿酸水平与颈动脉内一中膜厚度(IMT)的关系。方法检测96例中青年SCI患者(SCI组)及100名正常对照者(正常对照组)的血hs—CRP、Hcy、尿酸水平。患者均行颈动脉彩色多普勒超声检查，根据IMT将SCI组分为内膜正常亚组、内膜增厚亚组、稳定斑块亚

2、组及不稳定斑块亚组。结果SCI组血清hs—CRP、Hcy、尿酸水平及IMT均显著高于正常对照组(均P<0．001)。将SCI组患者分为内膜正常亚组16例，内膜增厚亚组34例，稳定斑块亚组28例，不稳定斑块亚组18例。与内膜正常亚组比较，内膜增厚、稳定斑块及不稳定斑块亚组的血hs—CRP、Hcy和尿酸水平显著增高(均P<0．01)。不稳定斑块亚组的血hs—CRP、Hcy和尿酸水平显著高于内膜增厚亚组及稳定斑块亚组(均P<0．01)。Pearson相关性分析显示，SCI组颈动脉IMT与血hs—CRP、Hcy、尿酸水平呈正相关(r=0．891，r=

3、0．757，r=0．531；均P<0．o1)。结论血清hs—CRP、Hcy、尿酸水平与中青年患者颈动脉粥样硬化及其严重程度紧密相关。【关键词】无症状性脑梗死；高敏c反应蛋白；同型半胱氨酸；尿酸；颈动脉内一中膜厚度【中图分类号】R743【文献标识码】A【文章编号】1004—1648(2014)04-0265-03RelationshipbetweenthelevelofserumhighsensitivityC-reactiveprotein，homocysteine，urineacidandthedegreeofcarotidintima--

4、mediathicknessinyoungandmiddle-agedpatientswithsilentcerebralinfarctionZHANGYah—ru，ZHANGLi—rain，CAOXiang—hui，eta1．DepartmentofNeurology，HebeiUnitedUniversityAfiliatedHospital，Tangshan063000，ChinaAbstract：0bjectiveToinvestigatetherelationshipbetweenthelevelofsePdmhigh—sensit

5、ivityC—reactiveprotein(hs·CRP)，Homocysteine(Hcy)，Uricacid(UA)andthedegreeofcarotidintinla—mediathickness(IMT)inyoungandmiddle—agedpatientswithsilentcerebralinfarction(SCI)．MethodsDetectedthelevelofseiumhs—CRP，HcyandUAin96youngandmiddle—agedpatientswithSCI(SCIgroup)and100nor

6、malcontrols(normalcontrolgroup)．AllpatientswereperformedthecarotidarterybytheDopplerultrasonography．SCIgroupwasdividedintocarotidintimanormalsubgroup，intimathickeningsubgroup，stableplaquesubgroupandunstableplaquesubgroupbasedonthedegreeofIMT．ResultsLevelsofserumhs—CRP，Hcy，U

7、AandthedegreeofIMTinSCIgroupweresignificantlyhigherthanthoseinnormalcontrolgroup(allP<0．001)．SCIpatientsweredividedintointimanormalsubgroup(16cases)，intimathickeningsubgroup(34cases)，stableplaquesubgroup(28cases)andunstab]eplaquesubgroup(18cases)．Comparedwithcarotidintimano

8、rmalsubgroup，levelsofselMnlhs—CRP，HcyandUAweresignificantlyincreasedinintimalthick