那格列奈对利伐沙班在大鼠体内药动学及药效学的影响

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1、授予单位代码10089学号或申请号13034HebeiMedicalUniversity硕士学位论文科学学位那格列奈对利伐沙班在大鼠体内药动学及药效学的影响作者姓名：崔文宁导师：王淑梅主任药师专业：药剂学二级学院：河北医科大学第二医院2015年03月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下,由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医_大学，试验材料、原始数据、申报的专利等知识产权均

2、归河北医科大学所有。否则,承担相应法律责任。•厂•jf.,.孑研究生签名：导师签章：分二级学院嶺#盖嘁^杂月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：>导师签章：目录中文摘要·············································································1英文摘要···················

3、··························································4研究论文那格列奈对利伐沙班在大鼠体内药动学及药效学的影响第一部分LC-MS/MS法测定大鼠血浆中利伐沙班浓度及那格列奈对利伐沙班药动学影响前言·············································································10材料与方法····································································11结

4、果·············································································16附图·············································································19附表·············································································31讨论·········································

5、····································41小结·············································································42参考文献·······································································26第二部分那格列奈对利伐沙班在大鼠体内药效学的影响前言·······························································

6、··············44材料与方法····································································44结果·············································································46附图·············································································49附表······························

7、···············································15讨论·············································································54小结·············································································54参考文献······································································

8、·54结论