无症状性2型糖尿病和高血压患者颅内动脉狭窄的筛查研究

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1、授予单位代码1»089m学号或申请号13191HebeiMedicalUniversity硕士学位论文在职科学学位无症状性2型糖尿病和高血压患者颅内动脉狭窄的筛查研究学位申请人：宋聪敏导师：王惠娟教授专业：神经病学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验

2、材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签名：导师签章：二级学院领导盖章：年+月如曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究土作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：导师签章：^年…月扣曰目录中文摘要································································

3、··············1英文摘要··············································································4英文缩写··············································································8研究论文无症状性2型糖尿病和高血压患者颅内动脉狭窄的筛查研究前言···················································

4、···························9材料与方法····································································11结果·············································································14附图·············································································1

5、6附表·············································································21讨论·············································································24结论·············································································29参考文献················

6、·······················································29综述颅内动脉狭窄与缺血性卒中的相关性································34致谢···················································································45个人简历································································

7、·············46中文摘要无症状性2型糖尿病和高血压患者颅内动脉狭窄的筛查研究摘要目的:以TCD与MRA相结合为研究手段，探讨2型糖尿病、高血压患者颅内动脉狭窄的危险性，给2型糖尿病和高血压患者的一级预防提供参考。方法:病例来源于2013年11月至2014年11月中国人民解放军252医院住院患者，共90例，病史10~15年。同时收集30例健康老年人做为对照，年龄60～75岁，其中男性58例，女性62例。研究分为4组。A组为30例单纯2型糖尿病患者，B组为30例单纯高血压病，C组为30例2型糖尿病合并高血压，D组

8、为30例健康老年人作为对照组。所有患者均进行TCD及MRA检测，将所得结果进行分析比较。结果：1共有90例患者入选，同时30例健康老年人作对照。年龄60～75岁，病史10~15年。平均年龄67.4士4.8岁。四组间性别、年龄差别均无统计学意义（P>0.05），均衡可比。2TCD及MRA结果：90例患者中