曲美他嗪对家兔急性房颤心房肌细胞内钙离子浓度的影响

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1、授予单位代码10089学号或申请号20123235HebeiMedicalUniversity硕士学位论文专业学位曲美他嗪对家兔急性房颤心房肌细胞内钙离子浓度的影响研究生：张晓杰导师：夏岳教授专业：内科学二级学院：第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、

2、申报的专利等知识产权均归河北医所有。否则，承担相应法律责任。丨“在、研究生签名导师签章：二级学院盖搴"“4'•河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除1文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。导师签章研究生签名：年3月日目录中文摘要·············································································1英文摘

3、要·············································································3英文缩写·············································································6研究论文曲美他嗪对家兔急性房颤心房肌细胞内钙离子浓度的影响前言···········································································

4、··7材料与方法····································································8结果·············································································10附图·············································································11附表··························

5、···················································12讨论·············································································14结论·············································································19参考文献················································

6、·······················20综述心房颤动时能量代谢研究进展·········································24致谢···················································································34个人简历·············································································35中 文 摘 要曲美他嗪对家兔

7、急性房颤心房肌细胞内钙离子浓度的影响摘要目的：心房颤动（atrialfibrillation,AF）是一种以心房不规则活动为特征的快速房性心律失常。心房颤动能够导致严重并发症，如心房内血栓形成、脑卒中、心力衰竭，从而导致房颤患者的病残率及病死率增加，现有关房颤的发病机制仍未完全阐明。近年来，提出了重构的观点，主要指心房重构，心房重构包括心房电重构和解剖重构，关于心房重构在房颤的2+分子生物学机制中的研究，也取得重大的进步。Ca超载是心房重构的重要机制，而大量研究表明：AF时心房肌细胞能量代谢发生改变与心房肌细胞内钙离子浓度有密切

8、关系，本研究通过快速心房起搏建立家兔心房颤2+动的动物模型，以及测定心房细胞内Ca浓度，探讨心肌能量代谢药物曲美他嗪对心房肌细胞内钙离子浓度的影响，进一步了解优化能量代谢是否能够减轻房颤时心房细胞内钙超载，从能量代谢水平为房颤的现代化治疗提供新的治疗思路。方法：