t细胞过继免疫治疗小鼠脑胶质瘤原位模型的研究

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1、授予单位代码10089学号或申请号20122473HebeiMedicalUniversity硕士学位论文科学学位T细胞过继免疫治疗小鼠脑胶质瘤原位模型的研究研究生：张静文导师：张宏义教授专业：外科学二级学院：唐山工人医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北

2、医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医所有。否则，承担相应法律责任。研宄生签名補b师签释级学院河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研宄工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研宄成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。欠^7知‘研宄生签名:n导师签章:y/r年）月M曰目录中文摘要····················································

3、························································1英文摘要············································································································4英文缩写··············································································

4、······························7研究论文T细胞过继免疫治疗小鼠脑胶质瘤原位模型的研究前言············································································································8材料与方法···············································································

5、···············10结果··········································································································17附图··········································································································21讨论·············

6、·····························································································31结论··········································································································35参考文献···········································

7、·······················································36综述恶性胶质瘤的细胞过继免疫治疗研究进展········································39致谢··················································································································48个人简历···········

8、·······························································································49T细胞过继免疫治疗小鼠脑胶质瘤原位模型的研究摘要恶性胶质瘤是最常见的原发性脑肿瘤之一，目前的主要治疗手段包括手术、放疗以及化疗，但即使这些治疗方法联合应用，胶质瘤病人的预后仍然较差。新兴的治疗方法包括免疫治疗、小分子靶向药物治疗以及基因治疗等，为胶质瘤的治疗提供了光明的前景。其