txnip介导的心肌微血管内皮细胞nlrp3炎性小体活化在心肌缺血再灌注损伤中的机制研究

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1、分类号R543.5UDC616.1密级公开TXNIP介导的心肌微血管内皮细胞NLRP3炎性小体活化在心肌缺血再灌注损伤中的机制研究许倡涛培养类别全日制学位类型学术学位一级学科(专业类)临床医学二级学科(专业)内科学（心血管病）研究方向冠心病指导教师陶凌教授培养单位西京医院心血管内科二O一五年五月第四军医大学硕士学位论文目录缩略语表······································································································

2、························1中文摘要······························································································································2英文摘要············································································································

3、··················5前言······························································································································9文献回顾····················································································································

4、·········11正文····························································································································16实验一在小鼠缺血再灌注模型上观察NLRP3炎性小体和TXNIP对心肌缺血再灌注损伤的影响·····················································································

5、····161材料·························································································································162实验方法·················································································································183结果·············

6、············································································································244讨论·························································································································30实验二在细胞模拟缺血再灌注损伤模型中观察TXNIP和NLRP3炎

7、性小体对心肌缺血再灌注损伤的影响·········································································311材料·························································································································312实验方法··············································

8、···································································323结果····················································