肝星状细胞在肝癌细胞恶性行为中的作用及机制研究

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1、分类号：R735.7单位代码：10312密级：学号：20122135博士学位论文题目：肝星状细胞在肝癌细胞恶性行为中的作用及机制研究研究生：张广指导教师：丁义涛教授学科专业：外科学学院名称：南京医科大学鼓楼临床医学院完成时间：二○一五年四月苗京医科大学博±学位论文南京医科大学学位论文原创性声明本人郑重声明，独立进巧研究工作所：所呈交的论文是本人在导师的指导下取得的成果。除了文中特别加＾＾标注引用的内容外，本论义不包含任何其他个人或集体已经发表或撰写的成果作品。对本文的研究做出重要贡献的个人和集体。，均己在文中Ｗ明确方式标明本人完全意识到本声明的法律后果

2、由本人承担。＇作者签名：杂日期：年月日［导师签名：日期；年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，同意学校保留并向国家有关部口或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权南京医科大学可臥将本学位论文的全部或部分内容编入有关数据库进行检索，可Ｗ采用影印、缩印或扫描等复制手段保存和汇编本学位讼文。作者签名：＾日期：年月日Ｉ导师签名日期：年月日南京医科大学博士学位论文目录中文摘要················································

3、········································1英文摘要························································································3第一部分绪论·················································································6第二部分肝星状细胞LX2引起HCC细胞对Sorafenib耐受的机制研究1.引言·································

4、····················································222.材料与方法············································································233.结果·····················································································374.讨论·····························································

5、························58第三部分肝星状细胞共培养引起HCC细胞EMT的机制研究1.前言·····················································································682.材料与方法············································································693.结果······························································

6、·······················764.讨论···················································································104全文总结·····················································································114综述······················································································

7、······115附录：缩略词表············································································138攻读博士期间发表论文情况·····························································140致谢·························································