食管癌长期生存患者临床特征及治疗相关因素分析

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1、授予单位代码10089学号或申请号20122382K妗(E钭大SHebeiMedicalUniversity科学学位食管癌长期生存患者临床特征及治疗相关因素分析研究生：李晓旭导师；韩春教授专业：肿瘤学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产

2、权均归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签章:^二级学院领导盖章：we年》月知曰河北医科大学研究生学位论文独创性声明本论文是、在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。7^1年》月如日目录中文摘要·············································································1英文摘要···············

3、······························································4英文缩写·············································································7研究论文食管癌长期生存患者临床特征及治疗相关因素分析前言·············································································8材料与方法··················

4、··················································8结果···········································································12附图···········································································16附表·······························································

5、············22讨论···········································································28结论···········································································30参考文献·····································································31综述食管癌综合治疗研究进展··············

6、·······························33致谢·················································································42个人简历···········································································43中文摘要食管癌长期生存患者临床特征及治疗相关因素分析摘要目的：观察和比较经三维适形放疗或调强放疗后的食管癌长期生存患者的临床特征及治疗相关因素，寻找生

7、存获益条件，为临床提供参考依据并指导治疗。方法：回顾性分析了2003年7月至2009年12月符合入组条件的食管癌患者913例，中位年龄66岁（30～89岁），其中男性564例，女性349例；非手术治疗TNM分期Ⅰ期69例，Ⅱ期188例，Ⅲ期656例。全部病例疗前检查未发现远处转移，均经病理证实为鳞癌。全组共263例患者接受了化疗，其中同步放化疗者174例。处方剂量50～70Gy，中位剂量60Gy，1.8～2Gy/次，5次/周。将全组患者按生存期长短分为两组：长期生存组（生存期≥60个月）和非长期生存组（生存期＜60个月）。观察两组的临床特征（

8、性别、年龄、肿瘤部位、长度、横向浸润宽度、周围器官受侵、临床分期、肿瘤体积）、近期疗效、治疗相关因素和急性毒副反应等的差异。并对全组患者的各项相关因素进行单因素及多