维生素d受体基因多态性与初治肺结核补充维生素d疗效相关性研究

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1、授了'单位代码10US9m学号或中请号13100HebeiMedicalUniversity硕士学位论文在职科学学位维生素D受体基因多态性与初治肺结核补充维生素D疗效相关性研究学位申请人：赵晓慧导师：田风军副主任医师专业：内科学二级学院：第三医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北

2、医科大学所有。否则，承担相应的法律责任。研究生签名赵樣I导师签章:砂等级学隱签章：fr年？月q曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导老师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名导师签章:•(r年3月q曰目录中文摘要·············································································1英文摘要·······················

3、······················································3英文缩写·············································································6研究论文维生素D受体基因多态性与初治肺结核补充维生素D疗效相关性研究前言·············································································8资料与方法································

4、····································10结果·············································································16附图·············································································35附表·············································································47讨论·····

5、········································································48结论·············································································55参考文献·······································································56综述一1,25-二羟维生素D的免疫调节机制研究现状······················63综述二维生素D

6、受体基因多态性与呼吸系统疾病························76致谢···················································································89个人简历·············································································91中文摘要维生素D受体基因多态性与初治肺结核补充维生素D疗效相关性研究摘要目的：对初治肺结核患者进行研究，治疗组在给予标准抗结核治疗方案的同时，以补充维生素D

7、作为辅助治疗，与对照组单纯给予标准抗结核治疗对比，观察维生素D对促进结核患者病情恢复是否有益，以及鉴于患者之间维生素D受体基因多态性的差别，观察维生素D受体基因型的不同与结核病情恢复之间是否存在关联。方法：采用病例对照研究，选取2014.01至2014.09于我院住院的初治肺结核患者作为研究对象，根据FokI位点进行维生素D受体基因分型检测，分为FF型、Ff型、ff型，将每型患者随机分入维生素D治疗组和空白对照组。治疗组给予异烟肼、利福平、吡嗪酰胺、乙胺丁醇标准强化抗结核治疗8周，同时给予补充维生素D每日800U，对照组仅给予异烟肼、利福