沧州地区新生儿先天性心脏病相关危险因素分析

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1、授予单位代码10089学号或申请号13201HebeiMedicalUniversity硕士学位论文在职科学学位沧州地区新生儿先天性心脏病相关危险因素分析学位申请人：陈静导师：赵建宏教授郝冀洪副教授专业：临床检验诊断学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权归河北医科大学所有。否则，承担相

2、应的法律责任。研究生签名:滅导师!-7H河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研宄工作及取得的研宄成果，除了文中特别加以标注等内容外，文中不包括其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要·············································································1英文摘要·············································································3研究论文沧

3、州地区新生儿先天性心脏病相关危险因素分析前言·············································································6材料与方法····································································7结果·············································································10附图··········································

4、···································13附表·············································································14讨论·············································································21结论·············································································23参考文献···············

5、························································24综述先天性心脏缺陷致病风险因素的研究进展··························28致谢···················································································43个人简历·············································································44中文摘要沧州地区新生儿先天性心脏病相关危险因素

6、分析摘要目的：出生缺陷是指由于遗传因素、环境因素或两者相互作用，致使正常的胚胎在发育过程中发生紊乱，引起胚胎或胎儿出生时就存在的结构和功能方面的异常。先天性心脏病（congenitalheartdisease，CHD）是最常见的出生缺陷，根据流行病学调查，我国围产儿CHD的患病率在0.69％~1.44％之间，在各种出生缺陷中占首位，是一种严重危害婴幼儿健康的先天畸形。文献报道，河北省CHD发病率为12.39/万，沧州市CHD发病率为13.04/万。CHD成为沧州地区常见出生缺陷病种之一，严重威胁患者的生命健康，也为家庭和社会带来沉重的负担。虽然有研究人员对CHD遗传学、表观遗传学和危险因素进

7、行过初步探讨，但将沧州市近十年间CHD的回顾性分析与对CHD的危险因素探究结合起来的综合研究尚属空白。本研究基于以往的研究成果和数据资料，分析近十年沧州市出生缺陷的地域分布情况；通过对围产期的孕产妇进行抽样调查研究，追踪胎儿及新生儿、婴儿常见CHD，探讨有机氯农药（organochlorinepesticides，OCPs）对CHD影响，并积极探索行之有效的预防措施。方法：1数据回顾性分析：分析近十年沧州地区