阿奇霉素联合雷贝拉唑、左氧氟沙星序贯治疗hp阳性慢性萎缩性胃炎的临床观察

《阿奇霉素联合雷贝拉唑、左氧氟沙星序贯治疗hp阳性慢性萎缩性胃炎的临床观察》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码１００８９学号或申请号１３４１１巧作ｄ钟少、５ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕±学位论文在职科学学位阿奇霉素联合雷贝拉嗤、左氧氣沙星序贯治疗Ｈｐ阳性慢性萎缩性胃炎的临床观察学位申请人；王艳飞导师；金玉怀教授专业；病原生物学二级学院；基础医学院２０１５年１０月河北医科大学学位论文使用授枚及知识产枚归属承语。本学位论文在导师（或指导小组）的指导下，由本人独立完成本学。位论文研究所获得的研究成果，其知识产权归河北

2、医科大学所有河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要一、内容相关的论文，第署名单位为河北医科大学，试验材料、原始数据申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责（研究生签名；导盖章；］辛导师签奪户级拳Ｐ领南；｜＾巧北医斜■大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加，指１＾标注等内容外，文中不包含其他人己发表或撰写的研究成果导教师对此进行了审定。本论文由本人独立撰写，文责自

3、负。．ｙｆ１＞研究生签名；坤如导师签章；畔ｆ’華月曰目录中文摘要··············································································1英文摘要··············································································3研究论文阿奇霉素联合雷贝拉唑、左氧氟沙星序贯治疗Hp阳性慢性萎缩性胃炎的临床观察前言·········

4、·····································································6材料与方法·····································································7结果··············································································9附表····························

5、··················································11讨论··············································································14结论··············································································20参考文献····································

6、····································21综述慢性萎缩性胃炎的诊治进展·············································25致谢····················································································34个人简历·································································

7、·············35中文摘要阿奇霉素联合雷贝拉唑、左氧氟沙星序贯治疗Hp阳性慢性萎缩性胃炎的临床观察摘要目的：慢性萎缩性胃炎（CAG）是消化系统常见疾病，主要病理特点是胃黏膜中固有腺体总数降低，甚至消失，除此之外，CAG胃黏膜中还存在上皮内瘤改变或肠腺化生，此类病理改变为胃癌的癌前病变。WHO于1978年便指出CAG可能和胃癌疾病的发生关系十分密切；其病因与发病机理十分复杂，确切的原因尚不明确，一般认为是综合因素所致。幽门螺杆菌(Hp)感染、胆汁反流、免疫因素、血管活性因子及细胞因子改变等都可能与

8、之有关。大量临床研究显示，CAG发生的重要病因之一为幽门螺杆菌(Hp)感染，据统计，Hp抗体能够在大部分的中重度CAG病人（80%）体内观察到。有研究显示如果患者有CagA基因，那么将更易发生疾病，推测原因可能因CagA的表达，可促进机体生成大量的细胞因子，诱导发生炎症，损伤黏膜，最终使腺体逐渐发生萎缩。对幽门螺杆菌感染者若不及时治疗，约1/3将发展为慢性萎缩性胃炎。近年来，CAG发病率逐步升高，并且呈现出年轻化