e-钙粘蛋白基因启动子区异常甲基化与子宫肌瘤的关联研究

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1、授予单位代鸪10089学号或申请号20123209HebeiMedicalUniversity硕士学位论文专业学位E-钙粘蛋白基因启动子区异常甲基化与子宫肌瘤的关联研究研究生：冉冉导师：康山教授专业：妇产科学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北

2、医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。研究生签名导师签章：二级学院领导签章：J年紐卻河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：4冉导师签章：年石月d日目录中文摘要·············································

3、···································1英文摘要··············································································4英文缩写················································································7研究论文E-钙粘蛋白基因启动子区异常甲基化与子宫肌瘤的关联研究前言················

4、································································8材料与方法·······································································9结果··············································································15附图···························

5、···················································17附表··············································································19讨论··············································································21结论··································

6、············································24参考文献········································································25综述子宫肌瘤及其相关遗传···················································29致谢······························································

7、······················45个人简历··············································································46中文摘要E-钙粘蛋白基因启动子区异常甲基化与子宫肌瘤的关联研究摘要目的：子宫肌瘤是妇女在生育年龄最常见的肿瘤，其发生率约为20～30%。虽然子宫肌瘤是良性肿瘤，但是它可以导致女性月经出血过多、慢性盆腔痛、反复流产、不孕等。子宫肌瘤的确切发病机制到目前仍不清楚。有研究表明子宫肌瘤的发生和发展

8、与一些肿瘤抑制基因的异常表达相关，例如：T-cadherin、p53、KLF11、DLEC1和KRT19等。肿瘤抑制基因的失活或者功能缺失可能是形成子宫肌瘤的原因之一。E-钙粘蛋白是一个重要的肿瘤抑制基因，属于细胞表面糖蛋白家族中的一员，它可以维持同质细胞间的粘附和保持组织结构的完整性。大量研究表明，E-钙粘蛋白的异常表达与许多上皮性肿瘤的侵袭和转移有关，包括子宫内膜癌、子宫颈癌、卵巢癌和肉瘤等。另外，E-钙粘蛋白的异常表达在一些良性侵袭性疾病的发生和发