e-钙粘蛋白基因多态性与子宫内膜异位症发病风险的关联性研究

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1、授予单位代码10089学号或申请号20122362HebeiMedicalUniversity硕士学位论文科学学位E-钙粘蛋白基因多态性与子宫内膜异位症发病风险的关联性研究研究生：李宾导师：康山教授李琰教授专业：妇产科学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，

2、第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。tV研究生签名:导师签章：二级学院领导盖章：7^/上年《月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：？年名月”日目录中文摘要······························

3、···············································1英文摘要·············································································5英文缩写·············································································9研究论文E-钙粘蛋白基因多态性与子宫内膜异位症发病风险的关联性研究前言····

4、·········································································10材料与方法····································································11结果·············································································18附图··················

5、···························································21附表·············································································26讨论·············································································30结论··························

6、···················································34参考文献·······································································34综述E-钙粘蛋白与子宫内膜异位症相关不孕的研究进展···············39致谢·············································································

7、······51个人简历·············································································52中文摘要E-钙粘蛋白基因多态性与子宫内膜异位症发病风险的关联性研究摘要目的：子宫内膜异位症(Endometriosis，EMs)是育龄期妇女的常见疾病，临床主要表现为进行性加重的痛经和不孕，严重影响育龄期妇女的健康和生育能力。目前，EMs的病因和发病机制仍不明确，普遍接受的是“子宫内膜种植学说”。但是随经血逆流的子宫内

8、膜碎片得以存活并致病，异位子宫内膜细胞的侵袭、转移能力对于异位病灶的形成起到了重要的作用。相关研究认为，异位的子宫内膜细胞可能通过上皮-间质转化获得侵袭能力而参与EMs的发病过程。2+E-钙粘蛋白（E-cadherin，CDH1）是上皮细胞表面Ca依赖性细胞粘附分子，主要参与形成上皮细胞之间的连接，是上皮细胞表面重要的分子标志，其表达水平降低将引起上皮细胞间连接系统的异常，使细胞的活动性增加，是发生上皮-间质转化的重要标志。相关研究证实，异位病灶处上皮细胞表面的E-cadherin