化疗药物白消安-环磷酰胺联用建立同种异基因小鼠的移植物抗宿主病(gvhd)模型

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1、分类号学号M201074855学校代码10487密级硕士学位论文化疗药物白消安-环磷酰胺联用建立同种异基因小鼠的移植物抗宿主病（GVHD）模型学位申请人：薛锋学科专业：免疫学指导教师：方敏教授龚非力教授答辩日期：2013年1月AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofMasterofMedicineCombinationofchemotherapeuticsofbusulfanandcyclophsphamideto

2、establishmodelofGVHDinallogeneicmiceCandidate：XueFengMajor:ImmunologySupervisor：Prof.FangMinProf.GongFeiliHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaDec,2012独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对

3、本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者

4、签名：指导教师签名：日期：年月日日期：年月日目录一、英文缩略词表·······························································1二、中文摘要·····································································2三、英文摘要·····································································4四、前言···············

5、·························································6五、材料与方法··································································7六、结果·······································································12七、讨论······················································

6、·················15八、小结·······································································17九、参考文献····································································18十、综述·······································································20十一、致谢·············

7、··························································25华中科技大学同济医学院硕士学位论文英文缩略词表ALLOAllogeneic同种异体的BMBonemarrow骨髓BMCBonemarrowcell骨髓细胞BMTBonemarrowtransplantation骨髓移植BUBusulfan白消安CYCyclophsphamide环磷酰胺DMSODimethylsulfoxide二甲基亚砜EDTAEthylendiaminotetraaceticacid乙二胺四乙

8、酸FCMFlowcytometry流式细胞术GVHDGraft-Versus-HostDisease移植物抗宿主病HMGB1High-mobilitygroupbox1人高迁移族蛋白1IHCImmunologicalHistologicalChemistry免疫