酿酒酵母多聚泛素基因UBI4参与调控氧化应激和复制性衰老的机制研究.pdf

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1、学校代码:10571学号:2015010088密级:公开酿酒酵母多聚泛素基因UBI4参与调控氧化应激和复制性衰老的机制研究TheroleofyeastpolyubiquitingeneUBI4inoxidativestressresponseandreplicativelifespanregulation医学学科门类临床检验诊断学学科、专业细胞衰老的分子机制研究方向二○一五级年级周涛研究生姓名刘新光教授导师姓名2015.9～2018.5起止日期二○一八年五月目录中文摘要...............................................

2、........................................................................1英文摘要.......................................................................................................................31前言....................................................................................

3、.......................................61.1研究背景................................................................................................................61.2研究目的................................................................................................................81.3研

4、究内容................................................................................................................82UBI4基因缺失酵母菌株复制寿命和抗氧化能力的测定....................................102.1材料与方法................................................................................................

5、..........102.2结果......................................................................................................................272.3讨论......................................................................................................................313酿酒酵母UBI4基因缺失对细胞早期凋亡的影

6、响..............................................343.1材料与方法..........................................................................................................343.2结果..................................................................................................................

7、....363.3讨论......................................................................................................................374过表达CTT1、CTA1和SOD2对UBI4基因缺失酵母菌株相关表型的影响.394.1材料与方法........................................................................................................

8、..394.2结果...