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1、ARTHRITIS&RHEUMATISMVol.65,No.5,May2013,pp1324–1334DOI10.1002/art.37890©2013,AmericanCollegeofRheumatologyCirculatingMicroRNAExpressionProfilesAssociatedWithSystemicLupusErythematosus1213AntingLiuCarlsen,AaronJ.Schetter,ChristofferT.Nielsen,ChristianLood,45236SteenKnudsen,AnneVoss,CurtisC.Har
2、ris,ThomasHellmark,MårtenSegelmark,731SørenJacobsen,AndersA.Bengtsson,andNielsH.H.HeegaardObjective.Toevaluatethespecificityofexpres-validationcohortcomprising68patientswithSLEandsionpatternsofcell-freecirculatingmicroRNAs(mi-68healthycontrolsubjects,andadiseasecontrolcohortRNAs)insystemiclup
3、userythematosus(SLE).comprising20patientswithSLE(19ofwhomwerefromMethods.TotalRNAwaspurifiedfromplasma,theothervalidationcohort),46healthycontrolsubjects,and45differentspecific,maturemiRNAsweredeter-38patientswithvasculitis,18patientswithrheumatoidminedusingquantitativereversetranscription–ar
4、thritis,and20immunosuppressedpatients.polymerasechainreactionassays.Atotalof409plasmaResults.SevenmiRNAswerestatisticallysignifi-sampleswereobtainedfrom364differentpatientswithcantlydifferentiallyexpressedinplasmafrompatientsSLE,healthycontrolsubjects,andcontrolsubjectswithwithSLE.Theexpressi
5、onofmiRNA-142-3p(miR-142-otherautoimmunediseases.Theresultsintheprimary3p)andmiR-181awasincreased,andtheexpressionofcohortof62patientswithSLEand29healthycontrolmiR-106a,miR-17,miR-20a,miR-203,andmiR-92awassubjectswerevalidatedin2independentcohorts:adecreased.Inaddition,theexpressionofmiR-342-
6、3p,miR-223,andmiR-20awassignificantlydecreasedinSupportedbytheDanishRheumatismAssociation(grantSLEpatientswithactivenephritis.ApredictivemodelR99-A1937).Drs.SchetterandHarris’workwassupportedbytheforSLEbasedon2or4miRNAsdifferentiatedpatientsIntramuralResearchProgramoftheNationalCancerInstitut
7、e,NIH.Drs.LoodandBengtsson’sworkwassupportedbytheMedicalFacultywithSLEfromcontrolsubjects(76%accuracy)whenatLundUniversity,theAlfredO¨sterlundFoundation,theCrafoordvalidatedindependently(P<2109).UseoftheFoundation,theSwedishRheumatismAssoci
