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1、MicroRNAExpressionDetectionMethodsZhiguoWanglBaofengYangMicroRNAExpressionDetectionMethodsDr.ZhiguoWangDr.BaofengYangMontrealHeartInstituteHarbinMedicalUniversityResearchCenterDept.Pharmacology5000BelangerStreet150086HarbinMontrealQCH1T1C8China,PeoplesRepublicCanadayangbf@ems.
2、hrbmu.edu.cnzhiguo.wang@icm-mhi.orgorwangz@mirna-tech.comISBN:978-3-642-04927-9e-ISBN:978-3-642-04928-6DOI10.1007/978-3-642-04928-6SpringerHeidelbergDordrechtLondonNewYorkLibraryofCongressControlNumber:PCNAppliedfor#Springer-VerlagBerlinHeidelberg2010Thisworkissubjecttocopyrig
3、ht.Allrightsarereserved,whetherthewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broadcasting,reproductiononmicrofilmorinanyotherway,andstorageindatabanks.Duplicationofthispublicationorpartsthereofispermittedonly
4、undertheprovisionsoftheGermanCopyrightLawofSeptember9,1965,initscurrentversion,andpermissionforusemustalwaysbeobtainedfromSpringer.ViolationsareliabletoprosecutionundertheGermanCopyrightLaw.Theuseofgeneraldescriptivenames,registerednames,trademarks,etc.inthispublicationdoesnot
5、imply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantprotec-tivelawsandregulationsandthereforefreeforgeneraluse.Coverdesign:WMXDesignGmbH,Heidelberg,GermanyPrintedonacid-freepaperSpringerispartofSpringerScience+BusinessMedia(www.springer.com)PrefaceMi
6、croRNAs(miRNAs),endogenousnoncodingregulatorymRNAsof22-nucleotides,haverapidlyemergedasthecentralplayersingeneexpressionregulation.Owingtotheirever-increasingimplicationsinthecontrolofvariousbiologicalandpathologicalprocesses,miRNAshavenowbeenconsiderednovelbiomarkersofvariou
7、shumandiseasesincluding,cancer,viraldisease,cardiovas-culardisorders,metabolicdisturbances,etc.Particularexpressionprofileshavebeenassociatedwithparticularpathologicalstates.ExpressionprofilingofmiR-NAshavethereforebecomeextremelyimportantnotonlyforfundamentalistsbutalsoforclini
8、cians.However,themethodologiesusedfordetectingprotein-codingm
