两型tnf-α及其受体在小鼠心肌肥厚中作用及其机制

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1、分类号学号D200878251学校代码10487密级博士学位论文两型TNF-α及其受体在小鼠心肌肥厚中作用及其机制学位申请人：苗琨学科专业：内科学指导教师：汪道文教授答辩日期：2013年5月万方数据AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineEffectsandMechanismofdifferentialTumorNecrosisFactoralphaandTumorNecrosisFactorRec

2、eptorsinMicewithCardiacHypertrophyPh.D.Candidate:KunMiaoMajor:InternalMedicineSupervisor:Prof.DaowenWangHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2013万方数据独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做

3、出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年

4、月日日期：年月日万方数据目录中文摘要················································································1ABSTRCT·············································································7研究背景··············································································14第一部分不同T

5、NF-α受体对压力负荷诱导所致心肌肥厚小鼠的作用及其机制··············································································211.材料与方法··································································212.结果···········································································323.讨论·······

6、····································································48第二部分两型TNF-α对对压力负荷诱导所致心肌肥厚小鼠的作用及其机制·················································································501.材料与方法··································································502.结果·········

7、··································································543.讨论···········································································62第三部分初步探讨MDSC对在心力衰竭中的作用······················641.材料与方法··································································642.结果·

8、··········································································6