褪黑素抗小鼠胃癌作用及其膜受体机制研究

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1、分类号：R735.2学校代码：10392学科专业代码：100104学号：200902042福建医科大学博士研究生毕业论文褪黑素抗小鼠胃癌作用及其膜受体机制研究Inhibitoryeffectofmelatoninonmurinegastriccancerandtherelationshipwithmembranereceptors学位类型：医学博士所在学院：基础医学院研究生：徐丽学科、专业：病理学与病理生理学导师：周瑞祥教授研究起止日期：2009年9月至2012年3月答辩日期：2012年6月7日二○一二年三月1万方数据2万方数据目录中文

2、摘要···························································································1英文摘要···························································································3正文引言·············································································

3、····················6第一部分褪黑素体内抗小鼠胃癌作用及其对MT1、MT2的影响材料和方法················································································8结果···························································································17讨论······································

4、·····················································27小结···························································································30第二部分褪黑素体外抗小鼠胃癌细胞增殖作用及其对MT1、MT2的影响材料和方法·················································································31

5、结果···························································································39讨论···························································································53小结···············································································

6、············56第三部分MAPKs及PI3K-Akt信号通路在褪黑素抑制小鼠胃癌细胞增殖中的作用材料和方法中的作用中的作用·············································································PI3-Akt信号通路在褪黑素体内外抑制小鼠胃癌细····57胞增殖中的作用结果·······················································································

7、····……………………………60讨论···························································································65小结···························································································67结论······························································

8、··································68参考文献·······························································