基于txnip介导的血淤证微循环障碍探讨gio发病机制及丹参素的干预作用

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1、学校代码:10571学号:2015010141密级公开基于TXNIP介导的血淤证微循环障碍探讨GIO发病机制及丹参素的干预作用InvestigationofthepathogenesisofGIObasedonmicrocirculatorydisturbanceofbloodstasissyndromemediatedbyTXNIPanditsinterventionoftanshinol学科门类医学学科、专业药理学研究方向骨药理学二〇一五级年级层次(硕士博士)硕士研究生姓名赖文秀崔燎教授导师姓名杨亚军副教授起止日期2015.9

2、～2018.5二〇一八年五月目录中文摘要........................................................................................................................1Abstract........................................................................................................................

3、.91前言..........................................................................................................................181.1研究背景和意义...................................................................................................181.2国内外研究现状...................

4、................................................................................191.3研究假说...............................................................................................................231.4研究目的............................................................

5、...................................................241.5研究内容...............................................................................................................242利用GIO大鼠模型研究骨微循环障碍对骨形成的影响及丹参素的干预作用262.1研究目的.....................................................

6、..........................................................262.2实验材料...............................................................................................................262.3实验方法..................................................................................

7、.............................312.4实验结果...............................................................................................................392.5讨论.................................................................................................................

8、......593在细胞水平研究TXNIP介导血管生成障碍对骨形成的影响...........................663.1实验目的.............................................