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1、中国组织工程研究与临床康复第11卷第10期2007-03-11出版JournalofClinicalRehabilitativeTissueEngineeringResearchMarch11,2007Vol.11,No.10CRTER综述瘢痕疙瘩发病机制的研究动态★靳瑾,高建华DepartmentofPlasticResearchdevelopmentinthepathogenicmechanismofkeloidsSurgery,NanfangAbstractHospital,Guangzhou510515,GuangdongOBJECTIVE:To
2、summarizethepathogenyofkeloidsinmoleculargeneticsandbiochemistry,soastoprovideaProvince,Chinadependableevidenceforclinicaldiagnosisandtreatment.JinJin★,StudyingforDATASOURCES:Acomputer-basedonlinesearchofPubmedwasundertakenforarticlesrelatedtothepathogenyofmaster'sdegree,keloidsp
3、ublishedinEnglishfromJanuary1980toOctober2006withthekeywordof"keloids";meanwhile,wesearchedDepartmentofPlasticSurgery,NanfangCNKIfortherelatedChinesearticlespublishedbetweenJanuary1980andOctober2006withthesamekeywordinHospital,GuangzhouChinese.510515,GuangdongProvince,ChinaSTUDYS
4、ELECTION:Datawereselectedfirstlytochoosetheliteraturesaboutthepathogenyofkeloidsandtheluckyjinj@163.comfull-textswerelookedover.Inclusivecriteria:Thebiochemicalresearchesaboutthekeloidsandfibroblastsinkeloids.Correspondenceto:Exclusivecriteria:Relatedreviewarticles.GaoJian-hua,DA
5、TAEXTRACTION:681articlesonthepathogenyofkeloidswerecollectedand33ofthemwereselected,whichProfessor,Chiefphysician,Departmentwereinaccordancewiththecriteria.ofPlasticSurgery,DATASYNTHESIS:Keloidsisasevereprobleminplasticsurgerybecauseofthetraitsofovergrowth,impingingtheNanfangHosp
6、ital,Guangzhou510515,normaltissue,easytorecurafterremovedandbadcurativeeffect.Thepathogenyofkelodsisstillunclearsofar.InthisGuangdongProvince,article,wesummarizethelatestprogressintheresearchofthepathogenyofkeloidsfromtheinheritancemechanism,Chinafunctionoffibroblastsofkeloids,bi
7、oactivityandcollagenmetabolism.ItshowsthatgenedetectiontechniquehasReceived:2005-12-16becomeanimportantapproachanddevelopingtendencyfordiscoveryofpathogeny,whichisalsoprovidereliableAccepted:2006-12-08experimentalevidenceforfuturegenetherapy.CONCLUSION:Moreandmoreresearchesaboutt
8、helocationandcloneofrelatedvirulencegene
