补充叶酸及b族维生素对冠心病患者介入治疗后血管内皮功能的影响

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1、中国医师进修杂志2010年1月5日第33卷第1期ChinJPostgradMed，January52010，Vo1．33。No．1·35··临床论著·补充叶酸及B族维生素对冠心病患者介入治疗后血管内皮功能的影响吴晓杰李采杰【摘要】目的探讨在常规治疗基础上补充叶酸及B族维生素对冠心病患者介人治疗后血管内皮功能的改善作用。方法选择冠状动脉介入治疗后的冠心病患者80例，在常规治疗基础上按照随机数字表法随机分为两组，对照组40例给予常规治疗，治疗组40例在常规治疗的基础上加服叶酸15mg／d，维生素30mg／d，维生素B：75。随访6个月，观察两组同型半胱氨酸(Hcy)水平，并

2、以超声测定肱动脉血流介导的舒张功能(FMD)变化来评价血管内皮功能。结果治疗组与对照组治疗后血浆Hcy分别为(8．62±3．51)、(12．96±4．62)mol／L，较治疗前的(13．24±5．07)、(13．87±5．13)mol／L均有下降，且治疗组下降更明显，与对照组治疗后比较差异有统计学意义(P

3、，血管；维生素B，复合；叶酸TheefectsoffolicacidandBvitaminssupplementonvascularendothelialfunctioninpatien~ofcoronaryarterydiseasewhoundergoneinterventionaltherapyXiao-jie．LICai-j~．DepartmentofCardiology，TheSecondAffiliatedHospitalofQiqihaerMedicalc0，Heilon~iangQiqihaer161006，ChinaCorrespondingauthor

4、：Xiao-jie．Email：sdwlflh@126．corn【Abstract】ObjectiveToevaluatetheimprovementofendothelialfunctionbyfolicacidandBvitaminssupplementinpatientsofcoronaryarterydiseasewhoundergoneinterventionaltherapy．MethodsEitypatientsofcoronaryarterydiseasewhoundergoneinterventionaltherapyweredividedintotw

5、ogroups：controlgroup(40cases，routinetreatment)andtreatmentgroup(theothers，withroutinetreatmentplusorallytakenfolicacidandBvitamins，folicacid15mg／d，vitaminB1275I-Lg／d，vitaminB630mg／d，for6months)．Plasmahomocystine(Hcy)wasmeasuredbyfluorescencepolarizationimmunoassayandflow—mediateddilation

6、(FMD)ofthebrachialarteryWasassessedbyhighresolutionultrasoundbeforeandafter6months．ResultsAftertreatment，thelevelsofHcydecreasedobviouslyintreatmentgroup[(8．62±3．51)mol／L]thanthatincontrolgroup[(12．96±4．62)mol／L](P<0．01)．TheFMDwasincreasedsignificantlyintreatmentgroup[(4．22±1．46)％VS(8．74

7、±1．51)％，P<0．01]．ConclusionsRoutinetreatment，includingaspirinandstatins，significantlyimprovesendothelialfunctioninpatientswithcoronaryarterydisease．FolicacidandBvitaminssupplementmayexertbeneficialefectsonpatientswithcoronaryarterydisease．【Keywords】Coronarydisease；Endothel