塞来昔布抑制鼻咽癌细胞增殖的分子机制研究

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1、分类号学号D201078327学校代码10487密级博士学位论文博士学位论文塞来昔布抑制鼻咽癌细胞增殖的分子机制研究学位申请人：刘东伯学科专业：肿瘤学指导教师：胡国清教授答辩日期：2013-5AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineThemolecularmechanismsofcelecoxibintheinhibitionofnasopharyngealcarcinomacellsproliferat

2、ionD.Candidate:LiudongboMajor:OncologySupervisor:Prof.HuguoqingHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2013独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。

3、学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录英文缩略表····································

4、·····································1前言··················································································2中文摘要············································································7英文摘要······································································

5、······8论文正文··········································································13第一部分塞来昔布抑制鼻咽癌细胞增殖、诱导肿瘤细胞凋亡和细胞周期阻滞··········································································13第二部分塞来昔布抑制鼻咽癌细胞IL-6/STAT3信号通路激活·····26第三部分塞来昔布抑制鼻咽癌细胞AKT磷酸化·······················

6、··42综述················································································50致谢················································································68发表论文··········································································72华中科技大学博士学位论文英文缩略词表英文缩写英文全称

7、中文全称CoxCyclooxygenase环氧合酶StatSignaltransducersandactivatorsoftranscription信号转导与转录激活因子PI3KPhosphoinositide3-kinase磷脂酰肌醇-3激酶AKTProteinkinaseB蛋白激酶EBVEpstein-barrvirusEB病毒LMP1Latentmembraneprotein1潜伏膜蛋白1MAPKMitogen-activatedproteinkinase丝裂原活化蛋白激酶ERKExtracellularsignal-regulatedkina

8、se胞外信号调节激酶DMSODimethylSulphoxide二甲基亚砜PBSPhosphateBuffe