tlr4拮抗剂减轻小鼠脑出血的炎症损伤及机制

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1、分类号R743密级公开学号2002010113学校代码90031硕士学位论文*TLR4拮抗剂减轻小鼠脑出血的炎症损伤及机制王艳春指导教师杨清武教授导师组成员培养单位第三军医大学新桥医院神经内科临床医学申请学位类别硕士专业学位专业名称神经病学论文提交日期2013年5月论文答辩日期2013年5月答辩委员会主席孙红斌教授评阅人王学峰教授张吉强教授二〇一三年五月*国家自然科学基金资助(81070932，81271283)目录缩略语表....................................

2、..........................................................................................1英文摘要..............................................................................................................................3中文摘要........................

3、......................................................................................................5论文正文TLR4拮抗剂减轻小鼠脑出血的炎症损伤及机制.........................................7第一章前言..........................................................................

4、................................7第二章TLR4拮抗剂TAK242透过血脑屏障能力的检测.........................................92.1材料和方法...........................................................................................................92.2实验结果.........................

5、.....................................................................................112.3讨论..............................................................................................................132.4小结.........................................

6、.....................................................................14第三章TAK242对脑出血小鼠的脑保护作用...........................................................153.1材料和方法.........................................................................................

7、.................153.2实验结果..............................................................................................................233.3讨论...........................................................................................................

8、...293.4小结..............................................................................................................31第四章TAK242对脑出血后TLR4下游信号分子表达的影响................................324.1材料和方法.........................................................